Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

H Husi, MA Ward, JS Choudhary, WP Blackstock… - Nature …, 2000 - nature.com
N-methyl-D-aspartate receptors (NMDAR) mediate long-lasting changes in synapse strength
via downstream signaling pathways. We report proteomic characterization with mass …

[HTML][HTML] Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis

…, A Seereeram, CH Reynolds, MA Ward… - Journal of Biological …, 2007 - ASBMB
Tau in Alzheimer disease brain is highly phosphorylated and aggregated into paired helical
filaments comprising characteristic neurofibrillary tangles. Here we have analyzed insoluble …

[HTML][HTML] Proteomics characterization of abundant Golgi membrane proteins

AW Bell, MA Ward, WP Blackstock… - Journal of Biological …, 2001 - ASBMB
A mass spectrometric analysis of proteins partitioning into Triton X-114 from purified hepatic
Golgi apparatus (84% purity by morphometry, 122-fold enrichment over the homogenate for …

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase

…, KY Leung, HL Byers, MA Ward… - Journal of …, 2005 - Soc Neuroscience
Tau is a major microtubule-associated protein of axons and is also the principal component
of the paired helical filaments (PHFs) that comprise the neurofibrillary tangles found in …

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

…, HL Byers, KY Leung, MA Ward… - The FASEB …, 2008 - Wiley Online Library
Defective axonal transport has been proposed as an underlying mechanism that may give
rise to neurodegeneration. We investigated the effect of phosphorylation on the axonal …

[HTML][HTML] Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion

P Eaton, HL Byers, N Leeds, MA Ward… - Journal of Biological …, 2002 - ASBMB
We have developed methods that allow detection, quantitation, purification, and identification
of cardiac proteinsS-thiolated during ischemia and reperfusion. Cysteine was biotinylated …

Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins

…, M Fernández-Ocana, HL Byers, MA Ward… - Journal of …, 2008 - Am Soc Microbiol
The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F (APOBEC3F
[A3F]) and A3G proteins are effective inhibitors of infection by various retroelements and …

Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease

…, AJ Thompson, HL Byers, MA Ward… - Journal of …, 2010 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder where definite diagnosis
can only be made postmortem, and for which the most promising peripheral markers of …

The AHK-Wales Report Card 2018: Policy Measures-is it possible to 'score'qualitative data?

MR Ward, R Tyler, LC Edwards… - Health Promotion …, 2021 - academic.oup.com
Comprehensive and meaningful policy analysis in the field of physical activity is difficult, not
least because of the variable influence of other policy domains. However, in 2011 a Policy …

[HTML][HTML] Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn

…, P Derkinderen, KY Leung, HL Byers, MA Ward… - Molecular …, 2011 - Springer
Background Tau protein is the principal component of the neurofibrillary tangles found in
Alzheimer's disease, where it is hyperphosphorylated on serine and threonine residues, and …