Background and Objectives: Ultrasound-guided regional anesthesia is a rapidly growing
field. There exists little information regarding the competencies involved with such a practice. …

Autotaxin catalyzes the transformation of lyso-phosphatidylcholine in lyso-phosphatidic acid
(LPA). LPA is a phospholipid possessing a large panel of activity, in particular as a motility …

Primary hepatocyte cultures are considered as a useful in vitro system for pharmacological/toxicological
studies. Although expression of drug-metabolizing enzymes and canalicular …

Despite their high conductivity, factors such as being fragile enough to face processing
issues and interfacial incompatibility with lithium electrodes are some of the main drawbacks …

Quinone reductase 2 (QR2, EC 1.10.5.1) is an enzyme with a feature that has attracted
attention for several decades: in standard conditions, instead of recognizing NAD(P)H as an …

For a few years, in vitro models have been used as part of high-throughput screening (HTS)
programs to characterize metabolic stability, drug permeability and drug solubility. This has …

A strategy is presented to predict interindividual variation in drug plasma levels in vivo by
the use of physiologically based pharmacokinetic modeling and human in vitro metabolic …

… Author links open overlay panel Anne-Marie Chollet a , Thierry Le Diguarher a , Nathalie
Kucharczyk a , Armelle Loynel a , Marc Bertrand c , Gordon Tucker b , Nicolas Guilbaud b …

The synthesis and structure−activity relationship (SAR) studies of a series of cyclopentane
carboxylic acid matrix metalloproteinase (MMP) inhibitors are described. Potent and specific …

A novel series of potent and specific α v integrin antagonists has been obtained by aminoalkyl
substitutions on benzocyloheptene acetic acids as a rigid GD bioisostere. The preferred …