Structure and stereochemistry of the active metabolite of clopidogrel
JM Pereillo, M Maftouh, A Andrieu, MF Uzabiaga… - Drug metabolism and …, 2002 - ASPET
Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts
…, C Labouret, C Hervé, MF Uzabiaga… - Proceedings of the …, 2006 - National Acad Sciences
P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been
recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this …
recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this …
[HTML][HTML] SR-25990C
…, M MAFTOUH, A ANDRIEU, F UZABIAGA… - ly2874455inhibitor.com
Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the preven-tion of vascular thrombotic events in patients at risk. …
launched and is indicated for the preven-tion of vascular thrombotic events in patients at risk. …
New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino [(ethoxycarbonyl) imino] methyl] phenyl]-1, 3-thiazol-2 …
A Badorc, MF Bordes, P de Cointet, P Savi… - Journal of medicinal …, 1997 - ACS Publications
The platelet fibrinogen receptor GpIIb-IIIa is curently considered a target of choice for drugs
used in the prevention and treatment of thrombosis. Ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl)…
used in the prevention and treatment of thrombosis. Ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl)…
[PDF][PDF] Method development and validation for clopidogrel bisulphate and its related substances by fast LC
R Sharma, TK Mohan, G Lalitha, LS Rao… - Journal of Pharmacy …, 2011 - Citeseer
A Novel, simple and fast liquid chromatographic technique has been established for the
analysis of clopidogrel and its related substances. These methods also have capability to …
analysis of clopidogrel and its related substances. These methods also have capability to …
Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor
H Kaku, Y Nishizawa, N Ishii-Minami… - Proceedings of the …, 2006 - National Acad Sciences
Chitin is a major component of fungal cell walls and serves as a molecular pattern for the
recognition of potential pathogens in the innate immune systems of both plants and animals. In …
recognition of potential pathogens in the innate immune systems of both plants and animals. In …
A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion
GD Tribble, S Mao, CE James… - Proceedings of the …, 2006 - National Acad Sciences
Haloacid dehalogenase (HAD) family phosphatases are widespread in prokaryotes and are
generally involved in metabolic processes. Porphyromonas gingivalis, an invasive …
generally involved in metabolic processes. Porphyromonas gingivalis, an invasive …
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF
G Qin, R Kishore, CM Dolan, M Silver… - Proceedings of the …, 2006 - National Acad Sciences
The transcription factor E2F1 is known to regulate cell proliferation and has been thought to
modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in …
modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in …
[CITATION][C] The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them
P Ferrara, JM Herbert, MFU Hervé, JM Pereillo…