Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine
…, S Orr, MWH Coughtrie, DJ Boocock, ML Williams… - … Biomarkers & Prevention, 2002 - AACR
Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The …
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The …
Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis
…, MD Threadgill, RA Sharma, ML Williams… - … Biomarkers & Prevention, 2002 - AACR
Curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in
the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human familial APC. To aid the …
the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human familial APC. To aid the …
Effects of Dietary Curcumin on Glutathione S-Transferase and Malondialdehyde-DNA Adducts in Rat Liver and Colon Mucosa: Relationship with Drug Levels1
…, CR Ireson, RD Verschoyle, KA Hill, ML Williams… - Clinical Cancer …, 2001 - AACR
Curcumin prevents colon cancer in rodent models. It inhibits lipid peroxidation and
cyclooxygenase-2 (COX-2) expression and induces glutathione S-transferase (GST) enzymes. We …
cyclooxygenase-2 (COX-2) expression and induces glutathione S-transferase (GST) enzymes. We …
Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice
…, JH Lamb, PB Farmer, WP Steward, ML Williams - Clinical cancer …, 2004 - AACR
Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are promising cancer chemopreventive
agents in rodent models, but there is a paucity of data on their pharmacokinetics and …
agents in rodent models, but there is a paucity of data on their pharmacokinetics and …
Community trial of a faith-based lifestyle intervention to prevent diabetes among African-Americans
…, LB Williams, J Dias, JT Garvin, L Marion… - Journal of community …, 2016 - Springer
About 75 % of African-Americans (AAs) ages 20 or older are overweight and nearly 50 %
are obese, but community-based programs to reduce diabetes risk in AAs are rare. Our …
are obese, but community-based programs to reduce diabetes risk in AAs are rare. Our …
Physiological modeling of formulated and crystalline 3, 3′-diindolylmethane pharmacokinetics following oral administration in mice
…, A Gescher, WP Steward, ML Williams… - Drug Metabolism and …, 2004 - ASPET
3,3′-Diindolylmethane (DIM) is a naturally occurring indole, which is currently under
investigation as a potential chemopreventive agent. The concentrations of DIM in plasma, liver, …
investigation as a potential chemopreventive agent. The concentrations of DIM in plasma, liver, …
Design of a cluster-randomized controlled trial of a diabetes prevention program within African–American churches: The Fit Body and Soul study
LB Williams, RW Sattin, J Dias, JT Garvin… - Contemporary clinical …, 2013 - Elsevier
Evidence from varied community settings has shown that the Group Lifestyle Balance (GLB)
Program and other adaptations of the Diabetes Prevention Program (DPP) intervention are …
Program and other adaptations of the Diabetes Prevention Program (DPP) intervention are …
A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer
ML Williams, P Bhargava, I Cherrouk… - British journal of …, 2000 - Wiley Online Library
Aims To examine the relationship between cytochrome P450 2C19 (CYP2C19) genotype
and expressed metabolic activity in 16 patients with advanced metastatic cancer. Methods …
and expressed metabolic activity in 16 patients with advanced metastatic cancer. Methods …
Liquid chromatographic assay for the simultaneous determination of indole-3-carbinol and its acid condensation products in plasma
…, A Gescher, WP Steward, ML Williams - … of Chromatography B, 2003 - Elsevier
A high-performance liquid chromatographic method was developed for the simultaneous
determination of indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), [2-(indol-3-ylmethyl)-…
determination of indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), [2-(indol-3-ylmethyl)-…
Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats
ML Williams, DE Mager, H Parenteau, G Gudi… - Drug metabolism and …, 2004 - ASPET
The effect of protein calorie malnutrition (PCM) on the pharmacokinetics of ketamine (KET)
enantiomers has been investigated. Six control and six PCM rats were administered 85 mg/kg …
enantiomers has been investigated. Six control and six PCM rats were administered 85 mg/kg …