User profiles for Markus Fridén

Markus Friden

RIA iMed, AstraZeneca
Verified email at astrazeneca.com
Cited by 2284

[HTML][HTML] On the rate and extent of drug delivery to the brain

M Hammarlund-Udenaes, M Fridén, S Syvänen… - Pharmaceutical …, 2008 - Springer
To define and differentiate relevant aspects of blood–brain barrier transport and distribution
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …

Structure− brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

M Fridén, S Winiwarter, G Jerndal… - Journal of medicinal …, 2009 - ACS Publications
New experimental methodologies were applied to measure the unbound brain-to-plasma
concentration ratio (K p,uu,brain ) and the unbound CSF-to-plasma concentration ratio (K p,uu,…

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

M Friden, A Gupta, M Antonsson, U Bredberg… - Drug metabolism and …, 2007 - ASPET
Concentrations of unbound drug in the interstitial fluid of the brain are not rapidly measured
in vivo. Therefore, measurement of total drug levels, ie, the amount of drug per gram of brain, …

Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

M Fridén, F Bergström, H Wan, M Rehngren… - Drug Metabolism and …, 2011 - ASPET
Currently used methodology for determining unbound drug exposure in brain combines
measurement of the total drug concentration in the whole brain in vivo with estimation of brain …

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

M Friden, F Ducrozet, B Middleton, M Antonsson… - Drug metabolism and …, 2009 - ASPET
New, more efficient methods of estimating unbound drug concentrations in the central nervous
system (CNS) combine the amount of drug in whole brain tissue samples measured by …

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

M Fridén, H Ljungqvist, B Middleton… - Journal of Cerebral …, 2010 - journals.sagepub.com
A major challenge associated with the determination of the unbound brain-to-plasma
concentration ratio of a drug (K p,uu,brain ), is the error associated with correction for the drug in …

[HTML][HTML] Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

…, ST Buckley, TS Maurer, M Fridén - Pharmaceutical …, 2022 - Springer
Purpose More than 15 years have passed since the first description of the unbound brain-to-plasma
partition coefficient (K p,uu,brain ) by Prof. Margareta Hammarlund-Udenaes, which …

[HTML][HTML] The brain slice method for studying drug distribution in the CNS

I Loryan, M Fridén, M Hammarlund-Udenaes - Fluids and Barriers of the …, 2013 - Springer
The high-throughput brain slice method is a precise and robust technique for estimating the
overall uptake of drugs into brain tissue through determination of the unbound volume of …

Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs

…, P Ewing, A Wigenborg, M Fridén - CPT …, 2016 - Wiley Online Library
Pulmonary drug disposition after inhalation is complex involving mechanisms, such as regional
drug deposition, dissolution, and mucociliary clearance. This study aimed to develop a …

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

H Chen, S Winiwarter, M Fridén, M Antonsson… - Journal of Molecular …, 2011 - Elsevier
Distribution over the blood–brain barrier (BBB) is an important parameter to consider for
compounds that will be synthesized in a drug discovery project. Drugs that aim at targets in the …