[HTML][HTML] Retroviral oncoprotein Tax induces processing of NF‐κB2/p100 in T cells: evidence for the involvement of IKKα

G Xiao, ME Cvijic, A Fong, EW Harhaj, MT Uhlik… - The EMBO …, 2001 - embopress.org
IκB kinase (IKK) is a key mediator of NF‐κB activation induced by various immunological
signals. In T cells and most other cell types, the primary target of IKK is a labile inhibitor of NF‐…

Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone

JB Cohen, SJ Schrauben, L Zhao, MD Basso, ME Cvijic… - Heart failure, 2020 - jacc.org
Objectives This study sought to assess if clinical phenogroups differ in comprehensive
biomarker profiles, cardiac and arterial structure/function, and responses to spironolactone …

Multiple plasma biomarkers for risk stratification in patients with heart failure and preserved ejection fraction

…, A Orlenko, L Zhao, MD Basso, ME Cvijic… - Journal of the American …, 2020 - jacc.org
Background Better risk stratification strategies are needed to enhance clinical care and trial
design in heart failure with preserved ejection fraction (HFpEF). Objectives The purpose of …

Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling

…, T Kita, E Reitman, D Vettori, ME Cvijic… - Annals of the new …, 2002 - Wiley Online Library
Mechanisms of cAMP signal transduction have been thoroughly investigated for more than
40 years. From the binding of hormonal ligands to their receptors on the outer surface of the …

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump

AD Rodrigues, Y Lai, ME Cvijic, LL Elkin… - Drug Metabolism and …, 2014 - ASPET
The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes
and plays an important role in the biliary clearance of bile acids (BAs). Therefore, any …

Discovery of clinical candidate BMS-906024: a potent pan-notch inhibitor for the treatment of leukemia and solid tumors

…, G Everlof, V Arora, DR Shen, ME Cvijic… - ACS medicinal …, 2015 - ACS Publications
Structure–activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides
identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. …

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases

…, C Xu, A Apedo, SC Traeger, ME Cvijic… - Journal of Medicinal …, 2021 - ACS Publications
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA
1 ) antagonist, with a human LPA 1 K b of 6.9 nM. The structure–activity relationship (SAR) …

Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types

J Ptacek, D Locke, R Finck, ME Cvijic, Z Li… - Laboratory …, 2020 - nature.com
An ability to characterize the cellular composition and spatial organization of the tumor
microenvironment (TME) using multiplexed IHC has been limited by the techniques available. …

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

…, S Deshpande, H Tang, ME Cvijic… - Journal of leukocyte …, 2017 - academic.oup.com
IFN-γ–inducible protein 10 (CXCL10), a chemokine that is abundantly secreted in response
to inflammatory stimuli, has been implicated in the pathogenesis of multiple inflammatory …

Body composition, natriuretic peptides, and adverse outcomes in heart failure with preserved and reduced ejection fraction

S Selvaraj, J Kim, BA Ansari, L Zhao, ME Cvijic… - Cardiovascular …, 2021 - jacc.org
Objectives The purpose of this study was to determine the relationship between body
composition, N-terminal B-type natriuretic peptide (NT-proBNP) levels, and heart failure (HF) …