The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced
liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative …

To understand the rate-limiting process of oral drug absorption, not only total bioavailability (F)
but also intestinal (F a · F g ) and hepatic (F h ) availability after oral administration should …

Three sulfotransferases (STs) catalysing the metabolic activation of potent carcinogenic
polycyclic arylmethanols were purified from female Sprague-Dawley (SD) rat liver cytosol …

In this study, advantages of minipigs to use in preclinical study for new drug development
were evaluated in terms of prediction of human pharmacokinetic (PK) parameters of various …

The purpose of this study was to evaluate the impact of intestinal efflux transporters on the
in vivo oral absorption process. Three model drugs—fexofenadine (FEX), sulfasalazine (SASP…

Purpose To evaluate the impact of intestinal first-pass metabolism (Fg) by cytochrome
P4503A (CYP3A) and uridine 5’-diphosphate-glucuronosyltransferases (UGT) on in vivo oral …

Although anatomical and structural similarities between the skin of minipigs and humans are
often reported, few percutaneous pharmacokinetic studies have been conducted in minipigs…

Tetrahydroquinoline (THQ) was deemed to be a suitable scaffold for our nonsteroidal selective
androgen receptor modulator (SARM) concept. We adapted the strategy of switching the …

Cynomolgus monkeys are widely used in preclinical studies during drug development
because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). …

CYP2C enzymes play key roles in drug metabolism, and clinical drug-drug interactions caused
by CYP2C induction have been reported. The aim of this study was to establish a method …