User profiles for Masanori Nakakariya
masanori nakakariyaTakeda Verified email at takeda.com Cited by 710 |
Physiologically‐based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future …
…, K Umehara, J Snoeys, M Nakakariya… - Clinical …, 2020 - Wiley Online Library
Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug interactions (…
quantitatively translate in vitro data and evaluate temporal effects from drug–drug interactions (…
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) …
…, KS Saikatendu, H Zou, M Nakakariya… - Journal of medicinal …, 2018 - ACS Publications
We report the discovery of 7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine derivatives
as a novel class of receptor interacting protein 1 (RIP1) kinase inhibitors. On the basis of the …
as a novel class of receptor interacting protein 1 (RIP1) kinase inhibitors. On the basis of the …
Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein
K Morimoto, M Nakakariya, Y Shirasaka… - Drug Metabolism and …, 2008 - ASPET
Oseltamivir (Tamiflu, Roche, Nutley, NJ), an ester-type prodrug of the anti-influenza drug Ro
64–0802 (oseltamivir carboxylate), has been reported to be associated with …
64–0802 (oseltamivir carboxylate), has been reported to be associated with …
[HTML][HTML] CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens
…, M Kuno, M Yoshikawa, S Shibata, M Nakakariya… - Scientific reports, 2017 - nature.com
The proof of target engagement (TE) is a key element for evaluating potential investment in
drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct …
drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct …
Identification and species similarity of OATP transporters responsible for hepatic uptake of β-lactam antibiotics
M Nakakariya, T Shimada, M Irokawa… - Drug metabolism and …, 2008 - jstage.jst.go.jp
The present study was designed to identify the organic anion transporting polypeptide (OATP)
molecule (s) responsible for the uptake of b-lactam antibiotics in human liver, using …
molecule (s) responsible for the uptake of b-lactam antibiotics in human liver, using …
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase …
…, T Mochida, S Takekawa, M Nakakariya… - Journal of Medicinal …, 2015 - ACS Publications
… Masanori Nakakariya … Masanori Nakakariya - Pharmaceutical Research Division, Takeda
Pharmaceutical Co., Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, …
Pharmaceutical Co., Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, …
[HTML][HTML] Pharmacological inhibition of monoacylglycerol O-acyltransferase 2 improves hyperlipidemia, obesity, and diabetes by change in intestinal fat utilization
…, T Maki, Y Satomi, M Hirayama, M Nakakariya… - PLoS …, 2016 - journals.plos.org
Monoacylglycerol O-acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DG),
a triacylglycerol precursor and potential peripheral target for novel anti-obesity …
a triacylglycerol precursor and potential peripheral target for novel anti-obesity …
In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes
M Nakakariya, M Ono, N Amano, T Moriwaki… - Drug Metabolism and …, 2012 - ASPET
It has been reported that in vivo biliary clearance can be predicted using sandwich-cultured
rat and human hepatocytes. The predicted apparent biliary clearance (CL bile, app ) from …
rat and human hepatocytes. The predicted apparent biliary clearance (CL bile, app ) from …
Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome
…, F Jacobs, X Chu, F Huth, M Nakakariya… - Molecular …, 2023 - ACS Publications
Madin–Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality.
Their low endogenous drug transporter protein levels make them an amenable system to …
Their low endogenous drug transporter protein levels make them an amenable system to …
Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis
T Iwanaga, M Nakakariya, H Yabuuchi… - Biological and …, 2007 - jstage.jst.go.jp
MATERIALS AND METHODS Chemicals [3H] Taurocholic acid (TCA; 1.92 TBq/mmol) was
purchased from PerkinElmer Life Sciences (Boston, MA, USA). Flutamide, hydroxyflutamide …
purchased from PerkinElmer Life Sciences (Boston, MA, USA). Flutamide, hydroxyflutamide …