User profiles for Masanori Nakakariya

masanori nakakariya

Takeda
Verified email at takeda.com
Cited by 710

Physiologically‐based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future …

…, K Umehara, J Snoeys, M Nakakariya… - Clinical …, 2020 - Wiley Online Library
Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug interactions (…

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) …

…, KS Saikatendu, H Zou, M Nakakariya… - Journal of medicinal …, 2018 - ACS Publications
We report the discovery of 7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine derivatives
as a novel class of receptor interacting protein 1 (RIP1) kinase inhibitors. On the basis of the …

Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein

K Morimoto, M Nakakariya, Y Shirasaka… - Drug Metabolism and …, 2008 - ASPET
Oseltamivir (Tamiflu, Roche, Nutley, NJ), an ester-type prodrug of the anti-influenza drug Ro
64–0802 (oseltamivir carboxylate), has been reported to be associated with …

[HTML][HTML] CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

…, M Kuno, M Yoshikawa, S Shibata, M Nakakariya… - Scientific reports, 2017 - nature.com
The proof of target engagement (TE) is a key element for evaluating potential investment in
drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct …

Identification and species similarity of OATP transporters responsible for hepatic uptake of β-lactam antibiotics

M Nakakariya, T Shimada, M Irokawa… - Drug metabolism and …, 2008 - jstage.jst.go.jp
The present study was designed to identify the organic anion transporting polypeptide (OATP)
molecule (s) responsible for the uptake of b-lactam antibiotics in human liver, using …

Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase …

…, T Mochida, S Takekawa, M Nakakariya… - Journal of Medicinal …, 2015 - ACS Publications
Masanori NakakariyaMasanori Nakakariya - Pharmaceutical Research Division, Takeda
Pharmaceutical Co., Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, …

[HTML][HTML] Pharmacological inhibition of monoacylglycerol O-acyltransferase 2 improves hyperlipidemia, obesity, and diabetes by change in intestinal fat utilization

…, T Maki, Y Satomi, M Hirayama, M Nakakariya… - PLoS …, 2016 - journals.plos.org
Monoacylglycerol O-acyltransferase 2 (MGAT2) catalyzes the synthesis of diacylglycerol (DG),
a triacylglycerol precursor and potential peripheral target for novel anti-obesity …

In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes

M Nakakariya, M Ono, N Amano, T Moriwaki… - Drug Metabolism and …, 2012 - ASPET
It has been reported that in vivo biliary clearance can be predicted using sandwich-cultured
rat and human hepatocytes. The predicted apparent biliary clearance (CL bile, app ) from …

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

…, F Jacobs, X Chu, F Huth, M Nakakariya… - Molecular …, 2023 - ACS Publications
Madin–Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality.
Their low endogenous drug transporter protein levels make them an amenable system to …

Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis

T Iwanaga, M Nakakariya, H Yabuuchi… - Biological and …, 2007 - jstage.jst.go.jp
MATERIALS AND METHODS Chemicals [3H] Taurocholic acid (TCA; 1.92 TBq/mmol) was
purchased from PerkinElmer Life Sciences (Boston, MA, USA). Flutamide, hydroxyflutamide …