User profiles for Masayuki Yamamoto

Masayuki Yamamoto

Tohoku University, Professor
Verified email at tohoku.ac.jp
Cited by 151987

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

…, N Hayashi, K Satoh, I Hatayama, M Yamamoto… - Biochemical and …, 1997 - Elsevier
The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

…, DR Roop, T Harada, JD Engel, M Yamamoto - Nature …, 2003 - nature.com
Transcription factor Nrf2 (encoded by Nfe2l2) regulates a battery of detoxifying and
antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1-deficient …

[HTML][HTML] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

…, H Yoshida, T Ishii, A Kobayashi, M Yamamoto… - Cell, 2007 - cell.com
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

…, K Tsuta, H Asamura, M Yamamoto… - Proceedings of the …, 2008 - National Acad Sciences
The nuclear factor E2-related factor 2 (Nrf2) is a master transcriptional activator of genes
encoding numerous cytoprotective enzymes that are induced in response to environmental and …

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

…, T Ishii, K Igarashi, JD Engel, M Yamamoto - Genes & …, 1999 - genesdev.cshlp.org
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

…, H Motohashi, K Tanaka, M Yamamoto - Nature cell …, 2010 - nature.com
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …

Nrf2–Keap1 defines a physiologically important stress response mechanism

H Motohashi, M Yamamoto - Trends in molecular medicine, 2004 - cell.com
The transcription factor Nrf2 regulates the basal and inducible expression of numerous
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

…, GE Mann, MP Murphy, M Yamamoto… - … Reviews Molecular Cell …, 2022 - nature.com
‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …

A cross-population atlas of genetic associations for 220 human phenotypes

…, S Koshiba, A Narita, T Konuma, K Yamamoto… - Nature …, 2021 - nature.com
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

…, T Chiba, K Igarashi, M Yamamoto - … and cellular biology, 2004 - Taylor & Francis
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes
and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In …