User profiles for Masayuki Yamamoto
Masayuki YamamotoTohoku University, Professor Verified email at tohoku.ac.jp Cited by 151987 |
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
…, N Hayashi, K Satoh, I Hatayama, M Yamamoto… - Biochemical and …, 1997 - Elsevier
The induction of phase II detoxifying enzymes is an important defense mechanism against
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
intake of xenobiotics. While this group of enzymes is believed to be under the transcriptional …
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
…, DR Roop, T Harada, JD Engel, M Yamamoto - Nature …, 2003 - nature.com
Transcription factor Nrf2 (encoded by Nfe2l2) regulates a battery of detoxifying and
antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1-deficient …
antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1-deficient …
[HTML][HTML] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
…, H Yoshida, T Ishii, A Kobayashi, M Yamamoto… - Cell, 2007 - cell.com
Inactivation of constitutive autophagy results in formation of cytoplasmic protein inclusions
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …
and leads to liver injury and neurodegeneration, but the details of abnormalities related to …
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
…, K Tsuta, H Asamura, M Yamamoto… - Proceedings of the …, 2008 - National Acad Sciences
The nuclear factor E2-related factor 2 (Nrf2) is a master transcriptional activator of genes
encoding numerous cytoprotective enzymes that are induced in response to environmental and …
encoding numerous cytoprotective enzymes that are induced in response to environmental and …
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …
the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These …
Nrf2–Keap1 defines a physiologically important stress response mechanism
H Motohashi, M Yamamoto - Trends in molecular medicine, 2004 - cell.com
The transcription factor Nrf2 regulates the basal and inducible expression of numerous
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
…, GE Mann, MP Murphy, M Yamamoto… - … Reviews Molecular Cell …, 2022 - nature.com
‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …
molecules with vastly different properties and biological functions that range from signalling to …
A cross-population atlas of genetic associations for 220 human phenotypes
…, S Koshiba, A Narita, T Konuma, K Yamamoto… - Nature …, 2021 - nature.com
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
…, T Chiba, K Igarashi, M Yamamoto - … and cellular biology, 2004 - Taylor & Francis
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes
and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In …
and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In …