Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function
…, H Débat, C Belloir, A Wiencis, M Sigoillot… - Chemical …, 2011 - academic.oup.com
Umami is the typical taste induced by monosodium glutamate (MSG), which is thought to be
detected by the heterodimeric G protein–coupled receptor, T1R1 and T1R3. Previously, we …
detected by the heterodimeric G protein–coupled receptor, T1R1 and T1R3. Previously, we …
[HTML][HTML] Domain-interface dynamics of CFTR revealed by stabilizing nanobodies
The leading cause of cystic fibrosis (CF) is the deletion of phenylalanine 508 (F508del) in the
first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance …
first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance …
A topological switch in CFTR modulates channel activity and sensitivity to unfolding
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is essential
to maintain fluid homeostasis in key organs. Functional impairment of CFTR due to …
to maintain fluid homeostasis in key organs. Functional impairment of CFTR due to …
Sweet-taste-suppressing compounds: current knowledge and perspectives of application
M Sigoillot, A Brockhoff, W Meyerhof… - Applied Microbiology and …, 2012 - Springer
Sweet-tasting compounds are recognized by a heterodimeric receptor composed of the
taste receptor, type 1, members 2 (T1R2) and 3 (T1R3) located in the mouth. This receptor is …
taste receptor, type 1, members 2 (T1R2) and 3 (T1R3) located in the mouth. This receptor is …
Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptor
E Maîtrepierre, M Sigoillot, L Le Pessot… - Protein expression and …, 2012 - Elsevier
The sweet taste receptor is a heterodimeric receptor composed of the T1R2 and T1R3 subunits,
while T1R1 and T1R3 assemble to form the umami taste receptor. T1R receptors belong …
while T1R1 and T1R3 assemble to form the umami taste receptor. T1R receptors belong …
Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastoris
M Sigoillot, A Brockhoff, E Lescop, N Poirier… - Applied microbiology …, 2012 - Springer
Gurmarin, a 35-residue polypeptide, is known to selectively inhibit responses to sweet
substances in rodents without affecting responses to other basic taste stimuli, such as NaCl, HCl, …
substances in rodents without affecting responses to other basic taste stimuli, such as NaCl, HCl, …
The crystal structure of gurmarin, a sweet taste–suppressing protein: Identification of the amino acid residues essential for inhibition
M Sigoillot, A Brockhoff, F Neiers, N Poirier… - Chemical …, 2018 - academic.oup.com
Gurmarin is a highly specific sweet taste–suppressing protein in rodents that is isolated from
the Indian plant Gymnema sylvestre. Gurmarin consists of 35 amino acid residues …
the Indian plant Gymnema sylvestre. Gurmarin consists of 35 amino acid residues …
Effects of typical inducers on olfactory xenobiotic-metabolizing enzyme, transporter, and transcription factor expression in rats
N Thiebaud, M Sigoillot, J Chevalier, Y Artur… - Drug metabolism and …, 2010 - ASPET
Several xenobiotic-metabolizing enzymes (XMEs) have been identified in the olfactory
mucosa (OM) of mammals. However, the molecular mechanisms underlying the regulation of …
mucosa (OM) of mammals. However, the molecular mechanisms underlying the regulation of …
Electrochemical detection of the 2-isobutyl-3-methoxypyrazine model odorant based on odorant-binding proteins: The proof of concept
We developed an electrochemical assay for the detection of odorant molecules based on a
rat odorant-binding protein (rOBP3). We demonstrated that rOBP3 cavity binds 2-methyl-1,4-…
rat odorant-binding protein (rOBP3). We demonstrated that rOBP3 cavity binds 2-methyl-1,4-…
Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751
C Grosse, M Sigoillot, V Megalizzi, A Tanina… - Journal of Structural …, 2024 - Elsevier
Ethionamide (ETO) is a prodrug that is primarily used as a second-line agent in the treatment
of tuberculosis. Among the bacterial ETO activators, the monooxygenase MymA has been …
of tuberculosis. Among the bacterial ETO activators, the monooxygenase MymA has been …