A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and
incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides…

Vasopeptidase inhibitors are single molecules that inhibit neutral endopeptidase (NEP) and
angiotensin-converting enzyme (ACE) simultaneously. Omapatrilat, the first in this new class …

Combined inhibition of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE)
produces cardiovascular effects greater than those elicited by selective inhibition of …

Combined neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) inhibition
produces greater acute hemodynamic effects than either treatment alone. We investigated …

A series of 7-(di)alkyl and spirocyclic substituted azepinones were generated and incorporated
as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. Clear …

The effect of endothelin-1 (ET-1) and big ET-1 on coronary flow and contractile function was
determined in isolated nonischemic and ischemic rat hearts. Both ET-1 (IC50 = 12 pMol) …

Unbound plasma concentrations may not reflect those in target tissues, and there is a need
for methods to predict tissue partitioning. Here, we investigate the unbound liver partitioning (…

Neutral endopeptidase inhibition (NEP-I) and angiotensin converting enzyme inhibition (ACE-I)
act synergistically to produce acute beneficial hemodynamic effects in models of heart …

In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …

The need to classify targets and features in high-resolution imagery is of interest in
applications such as detection of landmines in ground penetrating radar and tumors in medical …