Prediction of the clinical risk of drug-induced cholestatic liver injury using an in vitro sandwich cultured hepatocyte assay
T Susukida, S Sekine, M Nozaki, M Tokizono… - Drug Metabolism and …, 2015 - ASPET
Drug-induced liver injury (DILI) is of concern to the pharmaceutical industry, and reliable
preclinical screens are required. Previously, we established an in vitro bile acid–dependent …
preclinical screens are required. Previously, we established an in vitro bile acid–dependent …
Establishment of a drug-induced, bile acid–dependent hepatotoxicity model using HepaRG cells
T Susukida, S Sekine, M Nozaki, M Tokizono… - Journal of …, 2016 - Elsevier
Bile acid (BA) retention within hepatocytes is an underlying mechanism of cholestatic drug-induced
liver injury (DILI). We previously developed an assay using sandwich-cultured …
liver injury (DILI). We previously developed an assay using sandwich-cultured …
Metabolic activation of cholestatic drug-induced bile acid-dependent toxicity in human sandwich-cultured hepatocytes
E Ogimura, M Tokizono, S Sekine, T Nakagawa… - Journal of …, 2017 - Elsevier
We previously reported a cell-based toxicity assay using sandwich-cultured hepatocytes in
combination with a titrated amount of human bile acid (BA) species. In this assay, test …
combination with a titrated amount of human bile acid (BA) species. In this assay, test …