Triclosan: a widespread environmental toxicant with many biological effects
MF Yueh, RH Tukey - Annual review of pharmacology and …, 2016 - annualreviews.org
Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal
care products, including hand soaps and cosmetics, and impregnated in numerous different …
care products, including hand soaps and cosmetics, and impregnated in numerous different …
The commonly used antimicrobial additive triclosan is a liver tumor promoter
MF Yueh, K Taniguchi, S Chen… - Proceedings of the …, 2014 - National Acad Sciences
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum
antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, …
antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, …
[HTML][HTML] Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1
MF Yueh, YH Huang, A Hiller, S Chen… - Journal of Biological …, 2003 - ASBMB
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important physiological role by
contributing to the metabolism of endogenous substances such as bilirubin in addition to …
contributing to the metabolism of endogenous substances such as bilirubin in addition to …
[HTML][HTML] Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice
MF Yueh, RH Tukey - Journal of Biological Chemistry, 2007 - ASBMB
The formation of β-d-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases
(UGTs) is a significant metabolic pathway that facilitates the elimination of small …
(UGTs) is a significant metabolic pathway that facilitates the elimination of small …
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)
S Chen, MF Yueh, C Bigo, O Barbier… - Proceedings of the …, 2013 - National Acad Sciences
Camptothecin (CPT)-11 (irinotecan) has been used widely for cancer treatment, particularly
metastatic colorectal cancer. However, up to 40% of treated patients suffer from severe late …
metastatic colorectal cancer. However, up to 40% of treated patients suffer from severe late …
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2, 3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism …
…, S Chen, E Brace-Sinnokrak, JA Bonzo, MF Yueh… - Drug metabolism and …, 2007 - ASPET
The UDP-glucuronosyltransferase (UGT) 1A genes in humans have been shown to be
differentially regulated in a tissue-specific fashion. Transgenic mice carrying the human UGT1 …
differentially regulated in a tissue-specific fashion. Transgenic mice carrying the human UGT1 …
Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease
MF Yueh, F He, C Chen, C Vu… - Proceedings of the …, 2020 - National Acad Sciences
Triclosan (TCS), employed as an antiseptic and disinfectant, comes into direct contact with
humans through a plethora of consumer products and its rising environmental release. We …
humans through a plethora of consumer products and its rising environmental release. We …
Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
S Chouinard, MF Yueh, RH Tukey, F Giton, J Fiet… - The Journal of steroid …, 2008 - Elsevier
Conjugation by UDP-Glucuronosyltransferase (UGT) is the major pathway of androgen
metabolism and elimination in the human. High concentrations of glucuronide conjugates of …
metabolism and elimination in the human. High concentrations of glucuronide conjugates of …
Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies
W Lu, E Rettenmeier, M Paszek, MF Yueh… - Drug Metabolism and …, 2017 - ASPET
The gastrointestinal tract is enriched with xenobiotic processing proteins that play important
roles in xenobiotic bioactivation, metabolism, and detoxification. The application of …
roles in xenobiotic bioactivation, metabolism, and detoxification. The application of …
[PDF][PDF] Pregnane‐x‐receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice
S Chen, MF Yueh, RM Evans, RH Tukey - Hepatology, 2012 - Wiley Online Library
In humanized UDP glucuronosyltransferase‐1 (hUGT1) mice that express the entire UGT1
locus, the maternal hepatic UGT1A genes are dramatically induced 12‐14 days after …
locus, the maternal hepatic UGT1A genes are dramatically induced 12‐14 days after …