Chenodeoxycholic acid (CDCA) is a liver‐formed detergent and plays an important role in
the control of cholesterol homeostasis. During cholestasis, toxic bile acids (BA) accumulate in …

Bile acids subserve important physiological functions in the control of cholesterol homeostasis.
Indeed, hepatic bile acid synthesis and biliary excretion constitute the main route for …

Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes
belonging to the UDP‐glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is …

Castration-resistant prostate cancer (CRPC) is characterized by a shift in androgen receptor
(AR) signaling from androgen-dependent to androgen (ligand)-independent. UDP-…

Bile acids play important functions in the maintenance of bile acid homeostasis. However, due
to their detergent properties, these acids are inherently cytotoxic and their accumulation in …

Context: Androgens play major roles in prostate cancer initiation and development. In prostate
cells, the human uridine diphosphate-glucuronosyltransferase (UGT)2B15 and UGT2B17 …

Glucuronidation, catalyzed by uridine 5′‐diphospho‐glucuronosyltransferase (UGT)
enzymes, detoxifies cholestatic bile acids (BAs). We aimed to (i) characterize the circulating BA‐…

Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile
acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver …

Androgens are major regulators of prostate cell growth and physiology. In the human
prostate, androgens are inactivated in the form of hydrophilic glucuronide conjugates. These …

Obesity and diabetes are strongly associated not only with fatty liver but also cognitive
dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for …