User profiles for Mengxi Sun

Mengxi Sun

Postdoctoral Scholar, University of Chicago
Verified email at uchicago.edu
Cited by 911

Reversibility of liver fibrosis

M Sun, T Kisseleva - Clinics and research in hepatology and …, 2015 - Elsevier
Liver fibrosis is a serious health problem worldwide, which can be induced by a wide spectrum
of chronic liver injuries. However, until today, there is no effective therapy available for …

Nuclear-receptor–mediated regulation of drug–and bile-acid–transporter proteins in gut and liver

JL Staudinger, S Woody, M Sun, W Cui - Drug metabolism reviews, 2013 - Taylor & Francis
Adverse drug events (ADEs) are a common cause of patient morbidity and mortality and are
classically thought to result, in part, from variation in expression and activity of hepatic …

Preparation and antibacterial activities of polyaniline/Cu 0.05 Zn 0.95 O nanocomposites

X Liang, M Sun, L Li, R Qiao, K Chen, Q Xiao… - Dalton Transactions, 2012 - pubs.rsc.org
Polyaniline/Cu0.05Zn0.95O (PANI/CZO) nanocomposites were prepared by in situ inverse
microemulsion method. Based on the characterization of the crystal structure, chemical …

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

…, C Benner, S Heinz, SB Rosenthal, S Liang, M Sun… - Journal of …, 2020 - Elsevier
Background & Aims Chronic alcohol consumption is a leading risk factor for the development
of hepatocellular carcinoma (HCC), which is associated with a marked increase in hepatic …

[PDF][PDF] Batf pioneers the reorganization of chromatin in developing effector T cells via Ets1-dependent recruitment of Ctcf

…, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun… - Cell reports, 2019 - cell.com
The basic leucine zipper transcription factor activating transcription factor-like (Batf) contributes
to transcriptional programming of multiple effector T cells and is required for T helper 17 (…

[HTML][HTML] Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

…, X Liu, J Xu, M Zhang, M Sun… - The Journal of …, 2017 - Am Soc Clin Investig
Cholestatic liver fibrosis is caused by obstruction of the biliary tract and is associated with
early activation of portal fibroblasts (PFs) that express Thy-1, fibulin 2, and the recently …

[PDF][PDF] Poly (ADP-Ribose) links the DNA damage response and biomineralization

…, R Rajan, M Whitehead, AM Cobb, S Ahmad, M Sun… - Cell reports, 2019 - cell.com
Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate
mineralization of bone and the vasculature has devastating effects on patient health, yet an …

Transcriptional regulation of natural killer cell development and maturation

BL Kee, RE Morman, M Sun - Advances in immunology, 2020 - Elsevier
Natural killer cells are lymphocytes that respond rapidly to intracellular pathogens or cancer/stressed
cells by producing pro-inflammatory cytokines or chemokines and by killing target …

[HTML][HTML] Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas

ZY Zeng, HB Huang, LL Huang, MX Sun… - Science China Life …, 2014 - Springer
Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) tumorigenesis.
However, the mechanism(s) connecting EBV infection and NPC remain unclear. Recently, …

Runx2 (runt-related transcription factor 2) links the DNA damage response to osteogenic reprogramming and apoptosis of vascular smooth muscle cells

…, S Yusoff, R Hayward, S Ahmad, M Sun… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: The development of ectopic vascular calcification is strongly linked with organismal
aging, which is primarily caused by the accumulation of DNA damage over time. As Runx2 …