The polyamines putrescine, spermidine and spermine are natural components of all living
cells. Although their exact cellular functions are still largely unknown, a constant supply of …

Enhanced polyamine catabolism via polyamine acetylation-oxidation elevates the oxidative
stress in an organism due to increased production of reactive oxygen species (ROS). We …

Obesity is considered an important factor for many chronic diseases, including diabetes,
cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an …

Obesity is increasing in an epidemic manner in most countries and constitutes a public
health problem by enhancing the risk for diseases such as diabetes, fatty liver disease and …

Activation of polyamine catabolism through the overexpression of spermidine/spermine N 1 -acetyltransferase
(SSAT) in transgenic rodents does not only lead to distorted tissue …

Spermidine/spermine N 1 -acetyltransferase (SSAT), the rate-controlling enzyme in the
interconversion of spermidine and spermine, is regulated by polyamines and their analogs at …

We have earlier shown that α-methylated spermidine and spermine analogues rescue cells
from polyamine depletion-induced growth inhibition and maintain pancreatic integrity under …

Polyamines are essential for normal cellular growth and function. Activation of polyamine
catabolism in transgenic rats overexpressing spermidine/spermine N 1 -acetyltransferase, the …

Polyamines are essential molecules supporting the structure, conformation, and function of
nucleic acids and proteins. We studied stereoisomers of α,α′-dimethylated spermine [(R,R)-…

The pharmacological targeting of polyamine metabolism is currently under the spotlight for
its potential in the prevention and treatment of several age-associated disorders. Here, we …