[HTML][HTML] Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy

…, DS Adler, S Kollontzi, MJ Goedken… - Particle and Fibre …, 2020 - Springer
Background Plastic is everywhere. It is used in food packaging, storage containers,
electronics, furniture, clothing, and common single-use disposable items. Microplastic and …

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity

…, MJ Goedken, CE Rockwell, J Thomale… - … of Pharmacology and …, 2010 - ASPET
The use of the chemotherapeutic drug cisplatin is limited in part by nephrotoxicity. Cisplatin
causes renal DNA adducts and oxidative stress in rodents. The transcription factor Nrf2 (…

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

…, AL Slitt, JM Maher, LM Augustine, MJ Goedken… - Toxicology and applied …, 2008 - Elsevier
The transcription factor NFE2-related factor 2 (Nrf2) mediates detoxification and antioxidant
gene transcription following electrophile exposure and oxidative stress. Mice deficient in Nrf2 …

Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice

…, SA Reisman, RL Yeager, MJ Goedken… - … of Pharmacology and …, 2010 - ASPET
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) induces a battery of
cytoprotective genes after oxidative stress. Nrf2 aids in liver regeneration by altering insulin …

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice

…, LM Aleksunes, Y Tanaka, MJ Goedken… - Toxicological …, 2009 - academic.oup.com
Alpha-naphthyl isothiocyanate (ANIT) is a hepatotoxicant that produces acute intrahepatic
cholestasis in rodents. Farnesoid X receptor (FXR) and pregnane X receptor (PXR) are two …

[HTML][HTML] Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female …

…, TN Seymore, D Singh, KN Vayas, MJ Goedken… - Particle and Fibre …, 2023 - Springer
Background Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified
in both the indoor and outdoor environment. Detection of these materials in the air has …

[HTML][HTML] Ingested polystyrene nanospheres translocate to placenta and fetal tissues in pregnant rats: potential health implications

…, Z Yang, D Bitounis, M Polunas, MJ Goedken… - Nanomaterials, 2023 - mdpi.com
Recent studies in experimental animals found that oral exposure to micro- and nano-plastics
(MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although …

[HTML][HTML] Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice

X Wen, B Buckley, E McCandlish, MJ Goedken… - The American journal of …, 2014 - Elsevier
The chemotherapeutic drug cisplatin is actively transported into proximal tubules, leading to
acute renal injury. Previous studies suggest that the multidrug resistance–associated protein …

Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis

…, SM Street, MD Merrell, MJ Goedken… - Toxicological …, 2014 - academic.oup.com
Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the
fate of drugs, and alterations in liver function can place individuals at greater risk for adverse …

Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases

…, L Augustine, GL Scheffer, MJ Goedken… - Drug metabolism and …, 2007 - ASPET
Alterations in transporter expression may represent a compensatory mechanism of damaged
hepatocytes to reduce accumulation of potentially toxic compounds. The present study was …