We report the isolation of a cDNA that encodes the complete human androgen receptor. The
cDNA predicts a protein of 917 amino acids with a molecular weight of 98,918. Introduction …

Human genital skin fibroblasts contain both the full-length 110 K androgen receptor protein (AR-B,
apparent M r ≈ 110 000) and an 87 K N-terminally truncated AR isoform (AR-A, …

Huntington's and Kennedy's disease are autosomal dominant neurodegenerative diseases
caused by pathogenic expansion of polyglutamine tracts. Expansion of glutamine repeats …

Importance Male sex is a risk factor for developing severe COVID-19 illness. It is not known
whether sex hormones contribute to this predisposition. Objective To investigate the …

A cure for prostate cancer (CaP) will be possible only after a complete understanding of the
mechanisms causing this disease to progress from androgen dependence to androgen …

The isolation and cloning of a full-length cDNA insert complementary to mRNA encoding
human aromatase system cytochrome P-450 is reported. The insert contains an open reading …

Context: Patients with nonalcoholic fatty liver disease (NAFLD) are at increased risk of
cardiovascular disease, and atherogenic lipoproteins may play an important role. Objective: The …

The conversion of androgens to estrogens by aromatase cytochrome P450 (P450AROM) is
an important step in the mechanism of androgen action in the brain. In adult rats, P450AROM …

OBJECTIVE The 2019 Standards of Medical Care in Diabetes suggested that patients with
nonalcoholic fatty liver disease (NAFLD) should be evaluated for liver fibrosis. However, the …

The androgen receptor (AR) is a ligand-regulated member of the nuclear receptor superfamily.
The cyclin D1 gene product, which encodes the regulatory subunit of holoenzymes that …