The structure of P450 3A4 was determined by x-ray crystallography to 2.05-Å resolution.
P450 3A4 catalyzes the metabolic clearance of a large number of clinically used drugs, and a …

The structure of human P450 2C9 complexed with flurbiprofen was determined to 2.0 Å by
x-ray crystallography. In contrast to other structurally characterized P450 2C enzymes, 2C5, …

A 2.7-Å molecular structure of human microsomal cytochrome P450 2C8 (CYP2C8) was
determined by x-ray crystallography. The membrane protein was modified for crystallization by …

The xenobiotic metabolizing cytochromes P450 (P450s) are among the most versatile
biological catalysts known, but knowledge of the structural basis for their broad substrate …

Several antihistamine drugs including terfenadine, ebastine, and astemizole have been
identified as substrates for CYP2J2. The overall importance of this enzyme in drug metabolism …

The structure of the anti-inflammatory drug diclofenac bound in the active site of rabbit
microsomal cytochrome P450 2C5/3LVdH was determined by X-ray crystallography to 2.1 Å …

The structure of rabbit microsomal cytochrome P450 2C5/3LVdH complexed with a substrate,
4-methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)benzenesulfonamide (DMZ), was …

Individuals with drug metabolism polymorphisms involving CYP2C enzymes exhibit deficient
oxidation of important therapeutic agents, includingS-mephen-ytoin, omeprazole, warfarin, …

Carbamazepine (CBZ) is a widely prescribed anticonvulsant whose use is often associated
with idiosyncratic hypersensitivity. Sera of CBZ-hypersensitive patients often contain anti-…

Tolbutamide is a sulfonylurea-type oral hypoglycemic agent whose action is terminated by
hydroxylation of the tolylsulfonyl methyl moiety catalyzed by cytochrome P-450 (CYP) …