The Hydra chip multiprocessor (CMP) integrates four MIPS-based processors and their primary
caches on a single chip together with a shared secondary cache. A standard CMP offers …

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are
being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium …

WAVE2 is a member of the Wiskott–Aldrich syndrome protein family of cytoskeletal regulatory
proteins shown to link Rac activation to actin remodeling via induction of Arp 2/3 activity. …

FP8 is a natural progression for accelerating deep learning training inference beyond the 16-bit
formats common in modern processors. In this paper we propose an 8-bit floating point (…

Dual leucine zipper kinase (DLK, MAP3K12) is an essential driver of the neuronal stress
response that regulates neurodegeneration in models of acute neuronal injury and chronic …

Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and
neuronal cell death, yet the cellular pathways that underlie these processes remain largely …

Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator
of neuronal degeneration in multiple contexts. Here we describe the generation of potent …

The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms
has led to significant interest in discovering selective Jak2 inhibitors for use in treating …

10.7554/eLife.20725.001 The PKR-like endoplasmic reticulum kinase (PERK) arm of the
Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the …

In this work, we present a reinforcement learning (RL) based approach to designing parallel
prefix circuits such as adders or priority encoders that are fundamental to high-performance …