Background The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only
approved drug effective against the persistent liver stage of the hypnozoite forming strains …

In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side
effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8…

Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely
insoluble in water. In this study, solid dispersion method was used for DQ formulation …

Decoquinate has potent activity against both Plasmodium hepatic development and red cell
replication when tested in vitro. Decoquinate, however, is practically insoluble in water. To …

A series of 2-guanidino-4-oxoimidazoline (deoxo-IZ) derivatives was prepared and showed
potent antimalarial activities in rodent and Rhesus models. Compound 8e, the most potent …

4′-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from
an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/dose, …

Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models.
However, the low plasma levels and short half life of the drug do not adequately explain its in …

Muramic acid serves as a marker for the presence of bacterial cell wall debris in mammalian
tissues. There have been a number of controversial and sometimes conflicting results on …

A series of acid-stable carboxamide derivatives of 2-guanidinoimidazolidinedione (5a−c and
6a−c) were prepared as potential malaria prophylactic and radical cure agents. The new …

Phenoxypropoxybiguanides, such as 1 (PS-15), are prodrugs analogous to the relationship
of proguanil and its active metabolite cycloguanil. Unlike cycloguanil, however, 1a (…