Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat
MP Grillo, MT Lohr, JCM Wait - Drug Metabolism and Disposition, 2012 - ASPET
Carboxylic acid-containing nonsteroidal anti-inflammatory drugs (NSAIDs) can be metabolized
to chemically reactive acyl glucuronide and/or S-acyl-CoA thioester metabolites capable …
to chemically reactive acyl glucuronide and/or S-acyl-CoA thioester metabolites capable …
Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes
MP Grillo, JCM Wait, MT Lohr, S Khera… - Drug metabolism and …, 2010 - ASPET
Flunoxaprofen (FLX) is a chiral nonsteroidal anti-inflammatory drug that was withdrawn from
clinical use because of concerns of potential hepatotoxicity. FLX undergoes highly …
clinical use because of concerns of potential hepatotoxicity. FLX undergoes highly …
Covalent binding of phenylacetic acid to protein in incubations with freshly isolated rat hepatocytes
MP Grillo, MT Lohr - Drug metabolism and disposition, 2009 - ASPET
Phenylacetic acid (PAA) represents a substructure of a class of nonsteroidal anti-inflammatory
carboxylic acid-containing drugs capable of undergoing metabolic activation in the liver to …
carboxylic acid-containing drugs capable of undergoing metabolic activation in the liver to …
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor …
…, GR Tonn, KR Henne, MG Johnson, MT Lohr… - Drug metabolism and …, 2010 - ASPET
The 2-methyl substituted indole, 2MI [2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic
acid] is a potent dual inhibitor of 1) chemoattractant …
acid] is a potent dual inhibitor of 1) chemoattractant …
Interaction of γ-glutamyltranspeptidase with ibuprofen-S-acyl-glutathione in vitro and in vivo in human
MP Grillo, MT Lohr, S Khera - Drug Metabolism and Disposition, 2013 - ASPET
Ibuprofen is metabolized to chemically reactive acyl glucuronide and S-acyl-CoA metabolites
that are proposed to transacylate glutathione (GSH) forming ibuprofen-S-acyl-GSH (I-SG) …
that are proposed to transacylate glutathione (GSH) forming ibuprofen-S-acyl-GSH (I-SG) …
Bioactivation of a Novel 2-Methylindole Containing Dual CRTH2/DP Antagonist Leads to Mechanism-based CYP3A Inactivation: Glutathione Adduct Characterization …
…, GR Tonn, KR Henne, MG Johnson, MT Lohr… - Drug Metabolism and …, 2010 - ASPET
The 2-methyl substituted indole, 2MI, (2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic
acid) is a potent dual inhibitor of (1) chemoattractant …
acid) is a potent dual inhibitor of (1) chemoattractant …
[BOOK][B] Part I. Total Synthesis of Fendleridine and 1-Acetylaspidoalbidine. Part II. Identification of Selective Inhibitors of Poorly Characterized Serine Hydrolases PME …
AM Zuhl - 2012 - search.proquest.com
Complex natural products continue to inspire synthetic chemists to improve the state of the
art of synthetic organic chemistry. As part of these efforts, the Boger lab has pioneered the …
art of synthetic organic chemistry. As part of these efforts, the Boger lab has pioneered the …
[BOOK][B] Defining the relationship between glycolipid accumulation and neuronal dysfunction
D Pelled - 2003 - search.proquest.com
First and primarily I would like to thank my supervisor and advisor, Professor Tony Futerman,
for guidance and intelligent suggestions. On a more personal level, I would like to thank …
for guidance and intelligent suggestions. On a more personal level, I would like to thank …
Peptide metabolism and the control of body fluid homeostasis
PF Silveira, J Gil, L Casis… - … & Hematological Agents, 2004 - ingentaconnect.com
In this paper, we review our current understanding of the medicinal chemistry of the major
peptide systems, which influence body fluid homeostasis. Electrolytes play pivotal roles in intra…
peptide systems, which influence body fluid homeostasis. Electrolytes play pivotal roles in intra…