User profiles for Mohamed Hossam A Shahin

Mohamed H Shahin

Pfizer Inc.
Verified email at pfizer.com
Cited by 2581

Genetic and nongenetic factors associated with warfarin doserequirements in Egyptian patients

…, M El Shafey, SS Ali, MEF Mohamed… - Pharmacogenetics …, 2011 - journals.lww.com
Methods DNA was extracted from 207 patients taking warfarin for more than 2 months and
genotyped for VKORC1 (3673 G> A), CYP2C9* 2* 3* 4* 5* 8, CYP4F2 (V33M; rs2108622), …

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals

…, H Sagreiya, R Altman, MHA Shahin… - Clinical …, 2019 - Wiley Online Library
The cytochrome P450 ( CYP )4F2 gene is known to influence mean coumarin dose. The
aim of the present study was to undertake a meta‐analysis at the individual patients level to …

VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians

MHA Shahin, LH Cavallari, MA Perera… - Thrombosis and …, 2013 - thieme-connect.com
The VKORC1 Asp36Tyr single nucleotide polymorphism (SNP) is one of the most promising
predictors of high warfarin dose, but data on its population prevalence is incomplete. We …

[HTML][HTML] Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study

…, M Kawaguchi-Suzuki, JE Lang, MHA Shahin… - PloS one, 2013 - journals.plos.org
We sought to identify novel pharmacogenomic markers for HDL-C response to atenolol in
participants with mild to moderate hypertension. We genotyped 768 hypertensive participants …

CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers

…, BE Gawronski, TY Langaee, MHA Shahin… - Drug Metabolism and …, 2012 - ASPET
CYP2C9 is involved in metabolism of nearly 25% of clinically used drugs. Coding region
polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and …

[PDF][PDF] Neutrophil Respiratory Burst: an immunological indicator of post stroke infection

…, HM Elkady, DS Sheha, A Hossam… - Egyptian Journal of …, 2022 - ejimmunology.org
Stroke is long known to be followed by a series of immunosuppressive events, and infections
might be a cause of death after an acute insult of stroke. The aim of our work was to assess …

Study of serum syndecan-1 levels in a group of Egyptian juvenile systemic lupus erythematosus patients

…, HM Lotfy, YM Farag, RHED Mahfouz, RMH Shahin - Immunology …, 2017 - Elsevier
The aim of the study was to assess the serum levels of Syndecan-1 in a group of Egyptian
juvenile systemic lupus erythematosus (JSLE) patients and to study any possible associations …

Development and validation of a Behçet's Disease Damage Index for adults with BD: An Explicit, Composite and Rated (ECR) tool

…, RM Fawzy, NM Khalil, D Shahin… - International Journal …, 2021 - Wiley Online Library
Background Behçet's disease (BD) is a chronic multisystem variable vessel vasculitis. Disease
damage is irreversible and permanent. Validated tools evaluating damage are limited. …

[PDF][PDF] Safety of intravitreal anti-VEGF injections in diabetic macular edema

H Abouelkheir, MA ELShafie, MM Shahin… - Egyptian Journal of …, 2022 - researchgate.net
Propose: Diabetic macular edema (DME) is the most common cause of visual impairment in
patients with diabetes mellitus. The pathogenesis of DME is complex and multifactorial. …

Behçet's disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature

…, MI Abd-Elazeem, EA Said, NM Khalil, D Shahin… - Clinical …, 2019 - Springer
Objectives The present work was conducted to estimate the prevalence of adult Behçet’s
disease (BD) in adult Egyptian and to study the clinical pattern and influence of age at-onset …