We demonstrate that by altering the length of Cas9-associated guide RNA (gRNA) we were
able to control Cas9 nuclease activity and simultaneously perform genome editing and …

A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device
libraries. Here we present a modular transcriptional repression architecture based on …

Tissue homeostasis requires an effective, limited wound-healing response to injury. In chronic
disease, failure to regenerate parenchymal tissue leads to the replacement of lost cellular …

Human induced pluripotent stem cells (hiPSCs) have potential for personalized and
regenerative medicine. While most of the methods using these cells have focused on deriving …

Liver is a central nexus integrating metabolic and immunologic homeostasis in the human
body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of …

Antigen cross‐presentation is a principal function of specialized antigen‐presenting cells of
bone marrow origin such as dendritic cells. Although these cells are sometimes known as “…

Endotoxin lipopolysaccharide (LPS) is known to cause liver injury primarily involving
inflammatory cells such as Kupffer cells, but few in vitro culture models are applicable for …

Hepatocytes comprise the majority of liver mass and cell number. However, in order to
understand liver biology, the non-parenchymal cells (NPCs) must be considered. Herein, a …

Aim: The aim of this study was to investigate the hypothesis that the opioid system is
involved in the development of hepatic fibrosis. Methods: The effect of naltrexone (an opioid …

OBJECTIVES: To investigate the effects of morphine on reperfusion injury due to testicular
torsion-detorsion (T/D). METHODS: We divided 36 adult male Sprague-Dawley rats into six …