Degradation of ginsenosides in humans after oral administration

MA Tawab, U Bahr, M Karas, M Wurglics… - Drug metabolism and …, 2003 - ASPET
Even though the degradation of ginsenosides has been thoroughly studied in animals and
in vitro using acids, enzymes, and intestinal bacteria, knowledge concerning the systemic …

Boswellia serrata: An Overall Assessment of In Vitro, Preclinical, Pharmacokinetic and Clinical Data

M Abdel-Tawab, O Werz… - Clinical pharmacokinetics, 2011 - Springer
Non-steroidal anti-inflammatory drug (NSAID) intake is associated with high prevalence of
gastrointestinal or cardiovascular adverse effects. All efforts to develop NSAIDs that spare the …

Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated …

…, A Bock, T Dingermann, M Abdel-Tawab… - Planta …, 2006 - thieme-connect.com
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand activated transcription
factor, belonging to the metazoan family of nuclear hormone receptors. Activation of …

[HTML][HTML] Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

M Heinrich, B Jalil, M Abdel-Tawab… - Frontiers in …, 2022 - frontiersin.org
Background: Research on medicinal plants and extracts derived from them differs from studies
performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or …

Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: A prospective, randomized, placebo‐controlled, double‐blind pilot trial

…, M Treier, SJ Wehrle, G Becker, M AbdelTawab… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Patients irradiated for brain tumors often suffer from cerebral edema and
are usually treated with dexamethasone, which has various side effects. To investigate the …

Metabolism of boswellic acids in vitro and in vivo

…, M Karas, M Schubert-Zsilavecz, M Abdel-Tawab - Drug metabolism and …, 2008 - ASPET
Boswellia serrata resin dry extract is among the few herbal remedies designated with an
orphan drug status for the treatment of peritumoral brain edema. In addition, boswellic acids (…

[HTML][HTML] Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract

…, G Appendino, M Schubert-Zsilavecz, M Abdel-Tawab - Fitoterapia, 2013 - Elsevier
The anti-inflammatory potential of Boswellia serrata gum resin extracts has been demonstrated
in vitro and in animal studies as well as in pilot clinical trials. However, pharmacokinetic …

Absorption, pharmacokinetics, and safety of triclosan after dermal administration

…, B Bastian, M Abdel-Tawab… - Antimicrobial agents …, 2010 - Am Soc Microbiol
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after
dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous …

[HTML][HTML] Extracting and analyzing pyrrolizidine alkaloids in medicinal plants: A review

T Kopp, M Abdel-Tawab, B Mizaikoff - Toxins, 2020 - mdpi.com
Pyrrolizidine alkaloids (PAs) are distributed in plant families of Asteraceae, Boraginaceae,
and Fabaceae and serve in the chemical defense mechanism against herbivores. However, …

In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins

…, O Werz, M Schubert-Zsilavecz, M Abdel-Tawab - Fitoterapia, 2013 - Elsevier
Boswellia serrata gum resin extracts (BSE) revealed potent anti-inflammatory actions in
preclinical and clinical studies. In 2002 BSE was assigned an orphan drug status by the …