Liraglutide is a novel once-daily human glucagon-like peptide (GLP)-1 analog in clinical use
for the treatment of type 2 diabetes. To study metabolism and excretion of [ 3 H]liraglutide, a …

Eosinophil degranulation is a characteristic feature of asthma and allergic rhinitis. However,
degranulated eosinophils have not been convincingly demonstrated in the common mouse …

Background In allergic diseases, eosinophils in affected tissues release granule proteins
with cytotoxic, immunoregulatory, and remodelling‐promoting properties. From recent …

Background: Clearance of tissue granulocytes is central to the resolution of airway inflammation.
To date the focus has been on apoptotic mechanisms of cell removal and little attention …

Bruton's tyrosine kinase (Btk) is thought to positively regulate mast cell activation, implying a
role in allergic responses. We have compared acute and late phase allergic airway …

Like other GLP-1 receptor agonists used for treatment of type 2 diabetes, liraglutide delays
gastric emptying. In this clinical absorption study, the primary objective was to investigate the …

In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no
harm and is associated with tolerance induction. Repeated exposure to aerosolized …

Traditionally, traffic and activation of eosinophils in asthmatic airways are thought to take
place during the late-phase allergic reaction. The present study tests the hypothesis that when …

Isolated blood eosinophils are routinely used to study eosinophil activation mechanisms.
However, as revealed by ultrastructural analysis, different isolation protocols may yield purified …

Eosinophils are considered essential in the pathogenesis of allergy. Reduced eosinophil
apoptosis is considered to be a key element in the formation of eosinophilia in allergic …