Recent progress in asymmetric bifunctional catalysis using multimetallic systems

M Shibasaki, M Kanai, S Matsunaga… - Accounts of chemical …, 2009 - ACS Publications
The concept of bifunctional catalysis, wherein both partners of a bimolecular reaction are
simultaneously activated, is very powerful for designing efficient asymmetric catalysts. Catalytic …

Cp*CoIII Catalyzed Site‐Selective CH Activation of Unsymmetrical O‐Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes

B Sun, T Yoshino, M Kanai… - Angewandte Chemie …, 2015 - Wiley Online Library
The synthesis of isoquinolines by site‐selective CH activation of O‐acyl oximes with a Cp*Co
III catalyst is described. In the presence of this catalyst, the CH activation of various …

A Cationic High‐Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed CH Bond Activation

T Yoshino, H Ikemoto, S Matsunaga, M Kanai - Angewandte Chemie, 2013 - infona.pl
Aktiv ohne Aktivierung: In einem preiswerten und atomökonomischen Ansatz der C‐H‐Funktionalisierung
wird ein kationischer Cobalt(III)‐Komplex verwendet, um nucleophile …

A meta-selective C–H borylation directed by a secondary interaction between ligand and substrate

Y Kuninobu, H Ida, M Nishi, M Kanai - Nature Chemistry, 2015 - nature.com
Regioselective C–H bond transformations are potentially the most efficient method for the
synthesis of organic molecules. However, the presence of many C–H bonds in organic …

Copper‐Catalyzed Intramolecular C(sp3)H and C(sp2)H Amidation by Oxidative Cyclization

Z Wang, J Ni, Y Kuninobu, M Kanai - Angewandte Chemie, 2014 - Wiley Online Library
The first copper‐catalyzed intramolecular C(sp 3 )H and C(sp 2 )H oxidative amidation
has been developed. Using a Cu(OAc) 2 catalyst and an Ag 2 CO 3 oxidant in dichloroethane …

Asymmetric synthesis of tertiary alcohols and α-tertiary amines via Cu-catalyzed C− C bond formation to ketones and ketimines

M Shibasaki, M Kanai - Chemical reviews, 2008 - ACS Publications
Chiral tertiary alcohols and R-tertiary amines are important building blocks of naturally
occurring and artificial biologically active molecules. Although there are catalytic asymmetric …

Control of multivalent interactions by binding epitope density

CW Cairo, JE Gestwicki, M Kanai… - Journal of the American …, 2002 - ACS Publications
Receptor clustering by multivalent ligands can activate signaling pathways. In principle,
multivalent ligand features can control clustering and the downstream signals that result, but the …

Pyrroloindolone Synthesis via a Cp*CoIII-Catalyzed Redox-Neutral Directed C–H Alkenylation/Annulation Sequence

…, K Sakata, S Matsunaga, M Kanai - Journal of the …, 2014 - ACS Publications
A unique synthetic utility of a Cp*Co III catalyst in comparison with related Cp*Rh III catalysts
is described. A C2-selective indole alkenylation/annulation sequence proceeded smoothly …

Total synthesis of (±)-garsubellin A

…, H Usuda, K Yamatsugu, M Kanai… - Journal of the …, 2005 - ACS Publications
The first total synthesis of garsubellin A, a neurotrophic compound with potent choline
acetyltransferase-inducing activity, is described. Keys for success were (1) stereoselective …

Catalytic asymmetric synthesis of chiral tertiary organoboronic esters through conjugate boration of β-substituted cyclic enones

IH Chen, L Yin, W Itano, M Kanai… - Journal of the American …, 2009 - ACS Publications
The first catalytic enantioselective conjugate boration of β-substituted cyclic enones was
developed to produce enantiomerically enriched tertiary organoboronates. The optimized …