Adverse drug reactions (ADRs) are a major cause of hospital admissions, but recent data on
the incidence and clinical characteristics of ADRs which occur following hospital admission, …

Background Carbamazepine causes various forms of hypersensitivity reactions, ranging from
maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been …

Objective To ascertain the current burden of adverse drug reactions (ADRs) through a prospective
analysis of all admissions to hospital. Design Prospective observational study. Setting …

Aim To develop and test a new adverse drug reaction (ADR) causality assessment tool (CAT).
A comparison between seven assessors of a new CAT, formulated by an expert focus …

Given that cardiovascular safety liabilities remain a major cause of drug attrition during
preclinical and clinical development, adverse drug reactions, and post‐approval withdrawal of …

Drug-induced liver injury (DILI) is an important cause of serious liver disease. The antimicrobial
agent flucloxacillin is a common cause of DILI, but the genetic basis for susceptibility …

Background: A strong pharmacogenetic association has been reported in Chinese patients
between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced …

The role of the adaptive immune system in adverse drug reactions that target the liver has
not been defined. For flucloxacillin, a delay in the reaction onset and identification of human …

Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is increasingly …

Curcumin, a polyphenolic antioxidant derived from a dietary spice, exhibits anticancer activity
in rodents and in humans. Its efficacy appears to be related to induction of glutathione S-…