[HTML][HTML] The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

PJ Bosma, JR Chowdhury, C Bakker… - … England Journal of …, 1995 - Mass Medical Soc
Background People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia
in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, …

[HTML][HTML] Treatment of the Crigler–Najjar syndrome type I with hepatocyte transplantation

IJ Fox, JR Chowdhury, SS Kaufman… - … England Journal of …, 1998 - Mass Medical Soc
Crigler–Najjar syndrome type I is a recessively inherited disorder characterized by severe
unconjugated hyperbilirubinemia beginning at birth. The syndrome results from an absence of …

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

…, RPO Elferink, JR Chowdhury, NR Chowdhury… - Journal of Biological …, 1994 - Elsevier
Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase
activity toward bilirubin (B-UGT), resulting in severe non-hemolytic …

Genetic lesions of bilirubin uridine‐diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler‐Najjar and Gilbert syndromes: correlation of genotype …

…, G Sharma, JR Chowdhury, NR Chowdhury - Human …, 2000 - Wiley Online Library
Uridine‐diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes
that conjugate various endogenous and exogenous compounds with glucuronic acid and …

Glucuronidation and the UDP-glucuronosyltransferases in health and disease

PG Wells, PI Mackenzie, JR Chowdhury… - Drug metabolism and …, 2004 - ASPET
This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes

…, NR Chowdhury, AD Moscioni, M Kram, JR Chowdhury - Science, 1986 - science.org
Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion,
can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal …

Bilirubin metabolism: applied physiology

X Wang, JR Chowdhury, NR Chowdhury - Current Paediatrics, 2006 - Elsevier
Bilirubin is the breakdown product of the haem moiety of haemoglobin and other haemoproteins.
Because of internal hydrogen bonding, bilirubin is water-insoluble and requires enzyme…

[PDF][PDF] Sequence of exons and the flanking regions of human bilirubin‐UDP‐glucuronosyltransferase gene complex and identification of a genetic mutation in a patient …

PJ Bosma, NR Chowdhury, BG Goldhoorn… - …, 1992 - Wiley Online Library
Crigler‐Najjar syndrome, type I is a heterogeneous disorder that may result from mutations
of various regions of the bilirubin‐UDP‐glucuronosyltransferase gene complex that encodes …

Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation

…, GR Gorla, S Gagandeep, R Sokhi, N Roy-Chowdhury… - Cancer research, 1999 - AACR
Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT)
could improve survival, but curative RT may induce delayed life-threatening radiation-…

Alanine–glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer

…, A Santana, N Roy-Chowdhury… - Proceedings of the …, 2006 - National Acad Sciences
Mutations in the alanine–glyoxylate amino transferase gene (AGXT) are responsible for
primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate …