A fifth-generation model for receptor/gene-mediated corticosteroid effects was proposed
based on results from a 50 mg/kg IV bolus dose of methylprednisolone (MPL) in male …

FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is a new
sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of …

A mechanism-based model was developed to describe the time course of arthritis progression
in the rat. Arthritis was induced in male Lewis rats with type II porcine collagen into the …

A mechanism-based model for pharmacodynamic effects of dexamethasone (DEX) was
incorporated into our model for arthritis disease progression in the rat to aid in identification of …

Dexamethasone (DEX) is often given for the treatment of rheumatoid arthritis and clinical
dosing regimens of DEX have often been based empirically. This study tests whether the …

Purpose This study examines methylprednisolone (MPL) effects on the dynamics of hepatic
low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased …

Receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase (TAT)
were evaluated in normal rats. A group of normal male Wistar rats were injected with 50 …

A high-performance liquid chromatographic (HPLC) assay first described in 1979 has been
modified and revalidated for the simultaneous determination of prednisone, cortisol and …

An array of adverse steroid effects was examined on a whole body, tissue, and molecular
level. Groups of male adrenalectomized Wistar rats were subcutaneously implanted with Alzet …

Preterm birth produces neonatal respiratory distress syndrome, and dexamethasone (DEX)
is administered maternally to induce fetal lung maturation in women at risk of preterm delivery…