Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day …
A fifth-generation model for receptor/gene-mediated corticosteroid effects was proposed
based on results from a 50 mg/kg IV bolus dose of methylprednisolone (MPL) in male …
based on results from a 50 mg/kg IV bolus dose of methylprednisolone (MPL) in male …
Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2 [2-(-4-octylphenyl) ethyl] propane-1, 3-diol hydrochloride) in rats after oral and intravenous …
GML Meno-Tetang, H Li, S Mis, N Pyszczynski… - Drug Metabolism and …, 2006 - ASPET
FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is a new
sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of …
sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of …
Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis …
…, DC DuBois, DS Molano, NA Pyszczynski… - … of Pharmacology and …, 2008 - ASPET
A mechanism-based model was developed to describe the time course of arthritis progression
in the rat. Arthritis was induced in male Lewis rats with type II porcine collagen into the …
in the rat. Arthritis was induced in male Lewis rats with type II porcine collagen into the …
Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen …
…, DC DuBois, DS Molano, NA Pyszczynski… - … of Pharmacology and …, 2008 - ASPET
A mechanism-based model for pharmacodynamic effects of dexamethasone (DEX) was
incorporated into our model for arthritis disease progression in the rat to aid in identification of …
incorporated into our model for arthritis disease progression in the rat to aid in identification of …
Pharmacokinetics of dexamethasone in a rat model of rheumatoid arthritis
JC Earp, NA Pyszczynski, DS Molano… - … & drug disposition, 2008 - Wiley Online Library
Dexamethasone (DEX) is often given for the treatment of rheumatoid arthritis and clinical
dosing regimens of DEX have often been based empirically. This study tests whether the …
dosing regimens of DEX have often been based empirically. This study tests whether the …
Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats
Purpose This study examines methylprednisolone (MPL) effects on the dynamics of hepatic
low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased …
low-density lipoprotein receptor (LDLR) mRNA and plasma lipids associated with increased …
Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous …
Receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase (TAT)
were evaluated in normal rats. A group of normal male Wistar rats were injected with 50 …
were evaluated in normal rats. A group of normal male Wistar rats were injected with 50 …
Fifteen years of operation of a high-performance liquid chromatographic assay for prednisolone, cortisol and prednisone in plasma
WJ Jusko, NA Pyszczynski, MS Bushway… - … of Chromatography B …, 1994 - Elsevier
A high-performance liquid chromatographic (HPLC) assay first described in 1979 has been
modified and revalidated for the simultaneous determination of prednisone, cortisol and …
modified and revalidated for the simultaneous determination of prednisone, cortisol and …
Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats
An array of adverse steroid effects was examined on a whole body, tissue, and molecular
level. Groups of male adrenalectomized Wistar rats were subcutaneously implanted with Alzet …
level. Groups of male adrenalectomized Wistar rats were subcutaneously implanted with Alzet …
Modeling glucocorticoid-mediated fetal lung maturation: I. Temporal patterns of corticosteroids in rat pregnancy
MN Samtani, NA Pyszczynski, DC DuBois… - … of Pharmacology and …, 2006 - ASPET
Preterm birth produces neonatal respiratory distress syndrome, and dexamethasone (DEX)
is administered maternally to induce fetal lung maturation in women at risk of preterm delivery…
is administered maternally to induce fetal lung maturation in women at risk of preterm delivery…