Stereoselective Total Syntheses of Three Lycopodium Alkaloids, (−)-Magellanine, (+)-Magellaninone, and (+)-Paniculatine, Based on Two Pauson−Khand Reactions
T Kozaka, N Miyakoshi, C Mukai - The Journal of Organic …, 2007 - ACS Publications
The total syntheses of (−)-magellanine, (+)-magellaninone, and (+)-paniculatine were
completed from diethyl l-tartrate via the common intermediate in a stereoselective manner. The …
completed from diethyl l-tartrate via the common intermediate in a stereoselective manner. The …
Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in …
…, T Terasaki, C Mukai, S Kitagaki, N Miyakoshi… - Drug Metabolism and …, 2008 - ASPET
Many anti-human immunodeficiency virus 1 nucleoside reverse-transcriptase inhibitors have
low central nervous system (CNS) distribution due in part to active efflux transport at the …
low central nervous system (CNS) distribution due in part to active efflux transport at the …
ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells
…, M Watanabe, C Mukai, S Kitagaki, N Miyakoshi… - Pharmaceutical …, 2006 - Springer
Purpose The purpose of this study was to clarify the localization and function of the ATP-binding
cassette transporter G2 (ABCG2; BCRP/MXR/ABCP) in retinal capillary endothelial cells…
cassette transporter G2 (ABCG2; BCRP/MXR/ABCP) in retinal capillary endothelial cells…
Formal synthesis of (+)-nakadomarin A
F Inagaki, M Kinebuchi, N Miyakoshi, C Mukai - Organic Letters, 2010 - ACS Publications
The formal synthesis of (+)-nakadomarin A was completed. The significant points of this
synthesis are the highly stereoselective formation of the diazatricyclo[6.4.0.0 ]dodecane skeleton …
synthesis are the highly stereoselective formation of the diazatricyclo[6.4.0.0 ]dodecane skeleton …
Total Synthesis of (+)-Achalensolide Based on the Rh (I)-Catalyzed Allenic Pauson− Khand-Type Reaction
T Hirose, N Miyakoshi, C Mukai - The Journal of Organic …, 2008 - ACS Publications
The first total synthesis of (+)-achalensolide was achieved from a commercially available d-(−)-isoascorbic
acid. The known epoxide, derived from d-(−)-isoascorbic acid, was converted …
acid. The known epoxide, derived from d-(−)-isoascorbic acid, was converted …
Synthesis of Hexahydropyrrolo[2,3-b]indole Alkaloids Based on the Aza-Pauson−Khand-Type Reaction of Alkynecarbodiimides
D Aburano, T Yoshida, N Miyakoshi… - The Journal of Organic …, 2007 - ACS Publications
Upon treatment with 30 mol % of Co 2 (CO) 8 and 30 mol % of TMTU in toluene at 70 C,
benzene-bridged alkynecarbodiimides efficiently underwent a ring-closing reaction to give the …
benzene-bridged alkynecarbodiimides efficiently underwent a ring-closing reaction to give the …
Stereoselective Total Syntheses of Uncommon Sesquiterpenoids Isolated from Jatropha neopauciflora
Y Hayashi, N Miyakoshi, S Kitagaki, C Mukai - Organic letters, 2008 - ACS Publications
The first total syntheses of two tricyclic sesquiterpenes 1 and 2, isolated from Jatropha
neopauciflora , were completed from dimethyl d-tartrate in a stereoselective manner. The crucial …
neopauciflora , were completed from dimethyl d-tartrate in a stereoselective manner. The crucial …
First Total Synthesis of (−)-Ichthyothereol and Its Acetate
C Mukai, N Miyakoshi, M Hanaoka - The Journal of Organic …, 2001 - ACS Publications
The first and stereoselective total syntheses of (−)-ichthyothereol (1) and its acetate ((+)-2)
were achieved by incorporation of the two chiral centers of diethyl l-tartrate. The starting …
were achieved by incorporation of the two chiral centers of diethyl l-tartrate. The starting …
Total syntheses of naturally occurring diacetylenic spiroacetal enol ethers
N Miyakoshi, D Aburano, C Mukai - The Journal of Organic …, 2005 - ACS Publications
A highly stereoselective method for constructing a (2E)-methoxymethylidene-1,6-dioxaspiro[4.5]decane
skeleton has been developed on the basis of the palladium(II)-catalyzed ring-…
skeleton has been developed on the basis of the palladium(II)-catalyzed ring-…
First total synthesis of (−)-AL-2
N Miyakoshi, C Mukai - Organic Letters, 2003 - ACS Publications
Treatment of the 3,4-dioxygenated-9-hydroxy-1-nonyn-5-one derivative, derived from
diethyl l-tartrate, with a palladium catalyst in methanol under a CO atmosphere effected an …
diethyl l-tartrate, with a palladium catalyst in methanol under a CO atmosphere effected an …