Objective:The purpose of this study was to evaluate the rate of absorption and relative
bioavailability of caffeine from a Stay Alert® chewing gum and capsule formulation. Methods: This …

In order for therapeutic agents to exert their pharmacological effects, they have to cross the
biological membranes into the systemic circulation and reach the site of action. Drugs cross …

Purpose To investigate the transport of poly(amidoamine) (PAMAM) dendrimers with positive,
neutral and negatively charged surface groups across Caco-2 cell monolayers. Methods …

Objective—The purpose of this study was to determine the oral bioavailability and pharmacokinetics
of a glucosamine (GL) and the disaccharides of chondroitin sulfate (CS) after single …

Objective: The purpose of this report is to evaluate and present the results of analysis of
actual contents of several products in the marketplace containing glucosamine and/or …

We defined the pharmacokinetics of paclitaxel after iv, ip, po, and sc administration of 22.5
mg/kg to CD 2 F 1 mice. Additional mice were studied after iv bolus dosing at 11.25 mg/kg or 3…

Background The cytochrome P450 (CYP) oxidative enzyme system, located primarily in the
liver and small intestine, is responsible for metabolism and detoxification of numerous …

Due to the exceptional anticonvulsant activity displayed by substituted aniline enaminones,
related pyridine derivatives and phenothiazines synthesised in our laboratories, the further …

Enaminones, enamines of β‐dicarbonyl compounds, have been known for many years.
Their early use has been relegated to serving as synthetic intermediates in organic synthesis …

Previous studies suggest that P‐glycoprotein (P‐gp) modulates the PK/PD of many compounds
including opioid agonists and chemotherapeutic agents. The objective of this study was …