Inferential, robust non-negative matrix factorization analysis of microarray data
P Fogel, SS Young, DM Hawkins, N Ledirac - Bioinformatics, 2007 - academic.oup.com
Motivation: Modern methods such as microarrays, proteomics and metabolomics often produce
datasets where there are many more predictor variables than observations. Research in …
datasets where there are many more predictor variables than observations. Research in …
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and …
C Delescluse, N Ledirac, R Li, MP Piechocki… - Biochemical …, 2001 - Elsevier
Carbaryl and thiabendazole, two widely used pesticides, have been shown to induce cytochrome
P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [ 3 H] 2…
P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [ 3 H] 2…
Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species
N Ledirac, S Antherieu, AD d'Uby… - Toxicological …, 2005 - academic.oup.com
Organochlorine pesticides (OCs) are reported as potential carcinogens in humans. The aim
of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and …
of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and …
Endosulfan decreases cell growth and apoptosis in human HaCaT keratinocytes: Partial ROS‐dependent ERK1/2 mechanism
S Antherieu, N Ledirac, AP Luzy… - Journal of cellular …, 2007 - Wiley Online Library
Endosulfan is an organochlorine insecticide described as a potential carcinogen in humans.
This insecticide was recently reported to alter the mitogen‐activated protein (MAP) kinase …
This insecticide was recently reported to alter the mitogen‐activated protein (MAP) kinase …
The role of protein tyrosine kinases in CYP1A1 induction by omeprazole and thiabendazole in rat hepatocytes
G Lemaire, C Delescluse, M Pralavorio, N Ledirac… - Life sciences, 2004 - Elsevier
Benzimidazoles compounds like omeprazole (OME) and thiabendazole (TBZ) mediate
CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-…
CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-…
Carbaryl inducesCYP1A1gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor
N Ledirac, C Delescluse, G De Sousa… - Toxicology and applied …, 1997 - Elsevier
In spite of increasing numbers of insecticides used in agriculture, there are serious concerns
regarding the potential risks of exposure to these agents. Carbaryl is one of the most …
regarding the potential risks of exposure to these agents. Carbaryl is one of the most …
Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor
C Delescluse, N Ledirac, G De Sousa, M Pralavorio… - Toxicology letters, 1998 - Elsevier
Insecticides deserve particular attention since the general population is potentially exposed
to such chemicals through many routes. We therefore tested the comparative acute and …
to such chemicals through many routes. We therefore tested the comparative acute and …
Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types
C Delescluse, N Ledirac, G De Sousa, M Pralavorio… - Toxicology in vitro, 1997 - Elsevier
Hepatocytes and keratinocytes are among the most widely used cells in pharmaco-toxicology,
but a limitation of these models is the provision of human tissues on a regular basis. The …
but a limitation of these models is the provision of human tissues on a regular basis. The …
Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin
N Ledirac, G De Sousa, F Fontaine, C Agouridas… - Drug metabolism and …, 2000 - ASPET
The effects of various macrolide antibiotics [triacetyloleandomycin (TAO), clarithromycin,
azithromycin, roxithromycin, erythromycin base] and the new ketolide HMR3004 on CYP3A …
azithromycin, roxithromycin, erythromycin base] and the new ketolide HMR3004 on CYP3A …
Diflubenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells
N Ledirac, C Delescluse, P Lesca, MP Piechocki… - Toxicology and applied …, 2000 - Elsevier
Diflubenzuron (DFB) belongs to a group of compounds called benzoyphenyl ureas acting as
chitin synthesis inhibitors, which also inhibit growth of B16 murine melanomas. The present …
chitin synthesis inhibitors, which also inhibit growth of B16 murine melanomas. The present …