Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular
processes, including tumorigenesis, and its overexpression is observed in cell lines and …

Epidemiologic data of primary glomerular diseases in western France. Between January 1,
1976, and December 31, 2002, histologic diagnosis of primary glomerular diseases (PGD) …

Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of
arginines on proteins. Type I PRMTs and their substrates have been implicated in human …

5-Lipoxygenase is a key enzyme in the metabolism of arachidonic acid to leukotrienes. The
preventive efficacy of 5-lipoxygenase inhibitors against lung tumorigenesis was determined …

Acetylsalicylic acid (ASA) is known to prevent cancer development, but its mechanism of
action remains unclear. In this study, we compared the efficacies of this nonspecific …

The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5)
provides the scientific community with in vivo-active tool compound EPZ015666 (…

Inhibitors of the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2) may have
significant therapeutic potential for the treatment of B cell lymphomas and other cancer …

Activation of the fibroblast growth factor receptor FGFR4 by FGF19 drives hepatocellular
carcinoma (HCC), a disease with few, if any, effective treatment options. While a number of pan-…

A novel aryl pyrazole series of arginine methyltransferase inhibitors has been identified.
Synthesis of analogues within this series yielded the first potent, selective, small molecule …

BI 224436 is an HIV-1 integrase inhibitor with effective antiviral activity that acts through a
mechanism that is distinct from that of integrase strand transfer inhibitors (INSTIs). This 3-…