User profiles for Neville J Butcher
Neville J ButcherUniversity of Queensland Verified email at uq.edu.au Cited by 1958 |
Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials
GM Mortimer, NJ Butcher, AW Musumeci, ZJ Deng… - ACS …, 2014 - ACS Publications
While plasma proteins can influence the physicochemical properties of nanoparticles, the
adsorption of protein to the surface of nanomaterials can also alter the structure and function of …
adsorption of protein to the surface of nanomaterials can also alter the structure and function of …
Unravelling the stealth effect
NJ Butcher, GM Mortimer, RF Minchin - Nature nanotechnology, 2016 - nature.com
Poly (ethylene glycol) helps nanomaterials evade the immune system by modifying the
composition of proteins that are adsorbed on the surface of the materials.
composition of proteins that are adsorbed on the surface of the materials.
Hypoxia-mediated drug resistance in breast cancers
CE McAleese, C Choudhury, NJ Butcher, RF Minchin - Cancer letters, 2021 - Elsevier
Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances, …
tumor growth, including altered microvasculature structure, increased diffusional distances, …
Arylamine N-acetyltransferase 1: a novel drug target in cancer development
NJ Butcher, RF Minchin - Pharmacological reviews, 2012 - ASPET
The human arylamine N-acetyltransferases first attracted attention because of their role in
drug metabolism. However, much of the current literature has focused on their role in the …
drug metabolism. However, much of the current literature has focused on their role in the …
Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells
JM Tiang, NJ Butcher, RF Minchin - Biochemical and biophysical research …, 2010 - Elsevier
Arylamine N-acetyltransferase 1 is a phase II metabolizing enzyme that has been associated
with certain breast cancer subtypes. While it has been linked to breast cancer risk because …
with certain breast cancer subtypes. While it has been linked to breast cancer risk because …
[HTML][HTML] RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition
JM Tiang, NJ Butcher, C Cullinane, PO Humbert… - PloS one, 2011 - journals.plos.org
Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation
of arylamine and hydrazine substrates. It also has a role in the catabolism of the folate …
of arylamine and hydrazine substrates. It also has a role in the catabolism of the folate …
[HTML][HTML] Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and …
NJ Butcher, A Arulpragasam, RF Minchin - Journal of Biological Chemistry, 2004 - ASBMB
Many drugs and chemicals found in the environment are either detoxified by N-acetyltransferase
1 (NAT1, EC 2.3.1.5) and eliminated from the body or bioactivated to metabolites that …
1 (NAT1, EC 2.3.1.5) and eliminated from the body or bioactivated to metabolites that …
Arylamine n-acetyltransferase i
…, CR Wagner, F Rodrigues-Lima, NJ Butcher - The international journal …, 2007 - Elsevier
Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of
arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and …
arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and …
Effects of human arylamine N‐acetyltransferase I knockdown in triple‐negative breast cancer cell lines
JM Tiang, NJ Butcher, RF Minchin - Cancer medicine, 2015 - Wiley Online Library
Expression of human arylamine N‐acetyltransferase I ( NAT 1) has been associated with
various cancer subtypes and inhibition of this enzyme with small molecule inhibitors or si RNA …
various cancer subtypes and inhibition of this enzyme with small molecule inhibitors or si RNA …
Substrate-dependent regulation of human arylaminen-acetyltransferase-1 in cultured cells
NJ Butcher, KF Ilett, RF Minchin - Molecular pharmacology, 2000 - ASPET
Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely
distributed throughout the body. In the present study, we provide evidence for substrate-…
distributed throughout the body. In the present study, we provide evidence for substrate-…