Advancing from statistical associations of complex traits with genetic markers to understanding
the functional genetic variants that influence traits is often a complex process. Fine-…

The prostate cancer (PCa) risk-associated SNP rs11672691 is positively associated with
aggressive disease at diagnosis. We showed that rs11672691 maps to the promoter of a short …

Mitochondria (MT), the major site of cellular energy production, are under dual genetic control
by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the …

Background Photon-counting detector (PCD) CT and deep learning noise reduction may
improve spatial resolution at lower radiation doses compared with energy-integrating detector (…

Purpose The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based
pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large …

Objective To evaluate ultra-high-resolution (UHR) imaging of large joints using an
investigational photon-counting detector (PCD) CT. Materials and methods Patients undergoing …

Background & Aims Our purpose was to detect pancreatic ductal adenocarcinoma (PDAC)
at the prediagnostic stage (3–36 months before clinical diagnosis) using radiomics-based …

We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and
detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-…

Background Low values of high-sensitivity cardiac troponin (hs-cTn) and coronary artery
calcium (CAC) scores of zero are associated with a low risk for atherosclerotic cardiovascular …

Objective P-selectin is a cellular adhesion molecule that has been shown to be crucial in
development of coronary heart disease (CHD). We sought to determine the role of P-selectin on …