Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor
G Muccioli, N Pons, C Ghè, F Catapano… - European journal of …, 2004 - Elsevier
Besides possessing a strong growth hormone (GH)-releasing activity, the gastrointestinal
octanoylated peptide ghrelin has been reported to antagonize lipolysis in rat adipocytes. It is …
octanoylated peptide ghrelin has been reported to antagonize lipolysis in rat adipocytes. It is …
Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment
…, C Medana, F Restivo, MG Catalano, N Pons… - …, 2005 - academic.oup.com
Diabetics have at least twice the risk of stroke and may show performance deficit in a wide
range of cognitive domains. The mechanisms underlying this gradually developing end-organ …
range of cognitive domains. The mechanisms underlying this gradually developing end-organ …
Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high‐performance liquid …
…, GA Lord, C Kee Lim, N Pons - … in Mass Spectrometry …, 2006 - Wiley Online Library
Bilirubin is a protective antioxidant; however, when its conjugation and excretion are impaired,
as in neonatal and hereditary jaundice, bilirubin accumulates and may cause severe …
as in neonatal and hereditary jaundice, bilirubin accumulates and may cause severe …
Utilizing drug-drug interaction prediction tools during drug development: enhanced decision making based on clinical risk
…, GT Generaux, CC MacLauchlin, N Pons… - Drug metabolism and …, 2011 - ASPET
Several reports in the literature present the utility and value of in vitro drug-metabolizing
enzyme inhibition data to predict in vivo drug-drug interactions in humans. A retrospective …
enzyme inhibition data to predict in vivo drug-drug interactions in humans. A retrospective …
Bilirubin and uroporphyrinogen oxidation by induced cytochrome P4501A and cytochrome P4502B: role of polyhalogenated biphenyls of different configuration
F De Matteis, SJ Dawson, N Pons, S Pipino - Biochemical pharmacology, 2002 - Elsevier
In previous work it was shown that hepatic microsomes from rats treated with 3-methylcholanthrene
and similar inducers had increased bilirubin-degrading activity. The activity was …
and similar inducers had increased bilirubin-degrading activity. The activity was …
Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes: Increased bilirubin and uroporphyrinogen …
N Pons, S Pipino, F De Matteis - Biochemical pharmacology, 2003 - Elsevier
Polyhalogenated compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, are associated
with toxic Uroporphyria and cause alleviation of jaundice in the Gunn rat. These effects have …
with toxic Uroporphyria and cause alleviation of jaundice in the Gunn rat. These effects have …
Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4
P Motta, N Pons, S Pagliarusco, M Pellegatti… - Drug metabolism and …, 2011 - ASPET
Casopitant [1-piperidinecarboxamide,4-(4-acetyl-1-piperazinyl)-N-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethyl)-2-(4-fluoro-2-methylphenyl)-N-methyl-(2R,4S),
GW679769] has …
GW679769] has …
Chromogenic derivatives of AHTN (6-acetyl-1, 1, 2, 4, 4, 7-hexamethyltetralin) react with amino acids and protein in vitro. Spectral characteristics of the colour products
S Pipino, AM Api, N Pons, RL Smith… - Food and chemical …, 2004 - Elsevier
Three chromogenic products of AHTN have been detected after photo-oxidation and shown
to react with glycine or albumin, giving rise first to a blue color, followed by pink and, finally, …
to react with glycine or albumin, giving rise first to a blue color, followed by pink and, finally, …
[PDF][PDF] SB-773812: Correlation between in-silico and in-vivo metabolism
P Dua, R Gomeni, C Burgess, L Bertolotti, N Pons - page-meeting.org
Background SB-773812 is a molecule in development for schizophrenia and has been
specifically designed to target antagonism at those receptors believed to be associated with …
specifically designed to target antagonism at those receptors believed to be associated with …
Mitochondrial DNA abnormalities and autistic spectrum disorders
R Pons, AL Andreu, N Checcarelli, MR Vilà… - The Journal of …, 2004 - Elsevier
OBJECTIVES: To further characterize mtDNA defects associated with autistic features,
especially the A3243G mtDNA mutation and mtDNA depletion. STUDY DESIGN: Five patients …
especially the A3243G mtDNA mutation and mtDNA depletion. STUDY DESIGN: Five patients …