Aims Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme
1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and …

The contribution of CYP1A2 to the metabolism of the dietary heterocyclic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]…

The worldwide epidemic of obesity and the global incidence of cancer are both increasing.
There is now epidemiological evidence to support a correlation between obesity, weight gain, …

Consumption of cruciferous vegetables (CVs) is inversely correlated to many human
diseases including cancer (breast, lung, and bladder), diabetes, and cardiovascular and …

Consumption of red meat is associated with an increased risk of colorectal cancer, whereas
cruciferous vegetable consumption reduces cancer risk. While the mechanisms remain to be …

Elevated expression of cyclooxygenase-2 (COX-2), the inducible isoform of prostaglandin H
synthase, has been found in several human cancers, including colorectal cancer (CRC). …

Physical and chemical agents that induce DNA double-strand breaks (DSBs) are among the
most potent mutagens. The mammalian cell response to DSB comprises a highly co-…

With many safety and technical limitations partly mitigated through chemical modifications,
antisense oligonucleotides (ASOs) are gaining recognition as therapeutic entities. The …

Background Bariatric surgery, used to achieve effective weight loss in individuals with severe
obesity, modifies the gut microbiota and systemic metabolism in both humans and animal …

OBJECTIVES Post-operative atrial fibrillation (POAF) is the commonest post-operative
cardiac arrhythmia, affecting ∼1 in 3 patients undergoing coronary artery bypass grafting (CABG). …