Evaluation of carbazeran 4-oxidation and O6-benzylguanine 8-oxidation as catalytic markers of human aldehyde oxidase: impact of cytosolic contamination of liver …

J Xie, NF Saburulla, S Chen, SY Wong, ZP Yap… - Drug Metabolism and …, 2019 - ASPET
The present study investigated the contribution of microsomal cytochrome P450 and
cytosolic aldehyde oxidase-1 (AOX-1) to carbazeran 4-oxidation and O 6 -benzylguanine 8-…

In vitro inhibition of human aldehyde oxidase activity by clinically relevant concentrations of gefitinib and erlotinib: comparison with select metabolites, molecular …

…, P Sivanandam, EJH Goh, ZP Yap, NF Saburulla… - … of Pharmacology and …, 2020 - ASPET
Gefitinib and erlotinib are epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs)
with activity against metastatic non–small cell lung cancer. Aldehyde oxidase-1 (AOX1…

In Vitro Inhibition of Human Aldehyde Oxidase by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking …

…, P Sivanandam, EJH Goh, ZP Yap, NF Saburulla… - … of Pharmacology and …, 2020 - ASPET
Gefitinib and erlotinib are epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)
with activity against metastatic non-small cell lung cancer. Aldehyde oxidase-1 (AOX1) …

Evaluation of Carbazeran as an Enzyme‐Selective Substrate of Human Aldehyde Oxidase: Evidence for Regiospecific Oxidation of Carbazeran by CYP1A2, CYP2D6 …

AJ Lau, J Xie, NFDO Saburulla, S Chen… - The FASEB …, 2018 - Wiley Online Library
Aldehyde oxidase‐1 (AOX‐1) is a cytosolic xenobiotic‐metabolizing enzyme that has gained
increasing interest because of its emerging role in drug metabolism and toxicity. It is a …

[CITATION][C] Carbazeran 4-oxidation is catalyzed by human aldehyde oxidase-1 but not cytochrome P450 enzymes in human liver microsomes

NF Saburulla, AJ Lau - Drug Metabolism and Pharmacokinetics, 2017 - infona.pl
Nur Fazilah Saburulla, Aik Jiang Lau …