The P-glycoprotein multidrug transporter
O Fardel, V Lecureur, A Guillouzo - General Pharmacology: The Vascular …, 1996 - Elsevier
1. P-glycoprotein (P-gp) is a transmembrane protein involved in ATP-dependent efflux of
various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases …
various structurally unrelated anticancer drugs. Its overexpression in cancer cells decreases …
Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin
M Jaguin, N Houlbert, O Fardel, V Lecureur - Cellular immunology, 2013 - Elsevier
Monocytes/macrophages (MΦ), considered as plastic cells, can differentiate into either a pro-inflammatory
(M1) subtype, also known as a classically activated subtype, or an anti-…
(M1) subtype, also known as a classically activated subtype, or an anti-…
Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines
O Fardel, M Le Vée - Expert opinion on drug metabolism & …, 2009 - Taylor & Francis
… Bernard, 35043 Rennes, France +33 2 23 23 48 80; +33 2 23 23 47 94; olivier.fardel@univ-…
Bernard, 35043 Rennes, France +33 2 23 23 48 80; +33 2 23 23 47 94; olivier.fardel@univ-…
Bernard, 35043 Rennes, France +33 2 23 23 48 80; +33 2 23 23 47 94; olivier.fardel@univ-…
Physiological, pharmacological and clinical features of the multidrug resistance protein 2
O Fardel, E Jigorel, M Le Vee, L Payen - Biomedicine & Pharmacotherapy, 2005 - Elsevier
Multidrug resistance protein 2 (MRP2, ABCC2) is a drug efflux pump belonging to the ATP-binding
cassette (ABC) transporter superfamily. MRP2 is present predominantly at the biliary …
cassette (ABC) transporter superfamily. MRP2 is present predominantly at the biliary …
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human …
…, C Boursier-Neyret, Y Parmentier, O Fardel - Drug metabolism and …, 2006 - ASPET
Sinusoidal and canalicular hepatic drug transporters constitute key factors involved in drug
elimination from liver. Regulation of their expression via activation of xenosensors, such as …
elimination from liver. Regulation of their expression via activation of xenosensors, such as …
Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-α or interleukin-6
M Le Vee, V Lecureur, B Stieger, O Fardel - Drug metabolism and …, 2009 - ASPET
Tumor necrosis factor (TNF)-α and interleukin (IL)-6 are proinflammatory cytokines known to
alter expression of drug transporters in rodent liver. However, their effects toward human …
alter expression of drug transporters in rodent liver. However, their effects toward human …
Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
…, P Gripon, C Guguen-Guillouzo, O Fardel - European journal of …, 2006 - Elsevier
Functional expression of both sinusoidal and canalicular hepatic drug transporters was
investigated in the highly differentiated human hepatoma HepaRG cell line and also, for …
investigated in the highly differentiated human hepatoma HepaRG cell line and also, for …
Analysis of drug transporter expression in human intestinal Caco‐2 cells by real‐time PCR
…, M Audry, E Le Ferrec, S Bolze, O Fardel - Fundamental & …, 2007 - Wiley Online Library
Expression of drug transporters corresponds to a crucial parameter in intestinal Caco‐2
cells widely used for investigating drug absorption. In order to characterize it in an accurate, …
cells widely used for investigating drug absorption. In order to characterize it in an accurate, …
Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages
…, M Le Vee, L Amiot, R Fauchet, O Fardel - The Journal of …, 2003 - journals.aai.org
Polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene (BP) are ubiquitous
environmental carcinogenic contaminants exerting deleterious effects toward cells acting in the …
environmental carcinogenic contaminants exerting deleterious effects toward cells acting in the …
… -independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and …
…, C Morzadec, N Allain, O Fardel… - Free Radical Biology …, 2004 - Elsevier
Cadmium-induced cellular toxicity has been related to necrosis and/or caspase-dependent
apoptosis. In the present study, we show that, on cadmium exposure, the human …
apoptosis. In the present study, we show that, on cadmium exposure, the human …