Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10
O Kerdpin, PI Mackenzie, K Bowalgaha, M Finel… - Drug metabolism and …, 2009 - ASPET
An N-terminal domain histidine [corresponding to position 39 of UDP-glucuronosyltransferase
(UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro…
(UGT) 1A1] is conserved in all UGT1A and UGT2B subfamily proteins except UGT1A4 (Pro…
In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this …
O Kerdpin, KM Knights, DJ Elliot, JO Miners - Biochemical pharmacology, 2008 - Elsevier
In order to gain insights into the renal and hepatic glucuronidation of frusemide (FSM), this
study: (i) characterised the kinetics of FSM glucuronidation by human liver microsomes (HLM) …
study: (i) characterised the kinetics of FSM glucuronidation by human liver microsomes (HLM) …
Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9
O Kerdpin, DJ Elliot, PI Mackenzie, JO Miners - Drug metabolism and …, 2006 - ASPET
The uricosuric agent sulfinpyrazone (SFZ) is metabolized via C-glucuronidation, an
uncommon metabolic pathway, in humans. The present study aimed to characterize SFZ …
uncommon metabolic pathway, in humans. The present study aimed to characterize SFZ …
Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity
O Kerdpin, DJ Elliot, SL Boye, DJ Birkett… - Biochemistry, 2004 - ACS Publications
Selected active site residues in substrate recognition sites (SRS) 1 and 5 of cytochrome
P450 2C8 (CYP2C8) were mutated to the corresponding amino acids present in CYP2C9 to …
P450 2C8 (CYP2C8) were mutated to the corresponding amino acids present in CYP2C9 to …
Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9
Methods for the co-expression in Escherichia coli of human cytochrome P450 (CYP) 2C8 and
CYP2C9 with NADPH-cytochrome P450 reductase (OxR) to produce a catalytically active …
CYP2C9 with NADPH-cytochrome P450 reductase (OxR) to produce a catalytically active …
Cervical cancer markers: epigenetics and microRNAs
V Laengsri, U Kerdpin, C Plabplueng… - Laboratory …, 2018 - academic.oup.com
Gynecologic malignant neoplasms are a severe health problem among female patients, of
which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. …
which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. …
[HTML][HTML] Molecular basis of human cerebral malaria development
ST Wah, H Hananantachai, U Kerdpin… - Tropical medicine and …, 2016 - Springer
Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread
of malarial drug resistance and the lack of an effective vaccine are obstacles for disease …
of malarial drug resistance and the lack of an effective vaccine are obstacles for disease …
A clinical study of oral tori in southern Thailand: prevalence and the relation to parafunctional activity.
D Kerdpon, S Sirirungrojying - Eur J Oral Sci, 1999 - nature.com
Previous investigators have suggested that torus mandibularis (TM) may have environmental
as well as developmental origins. In a Thai dental hospital, 609 consecutive patients were …
as well as developmental origins. In a Thai dental hospital, 609 consecutive patients were …
Clinical and laboratory update on the DEL variant
…, J Thongbus, A Srisarin, U Kerdpin… - Laboratory …, 2014 - academic.oup.com
Serological assays for the RhD blood group are based on detection of the RhD antigen on
human red blood cells using a specific anti-D antibody. The weak expression of the RhD …
human red blood cells using a specific anti-D antibody. The weak expression of the RhD …
Factors related to delay in diagnosis of oral squamous cell carcinoma in southern Thailand
D Kerdpon, H Sriplung - Oral oncology, 2001 - Elsevier
The factors related to patient, professional and total delay in 161 oral squamous cell carcinoma
(OSCC) patients attending for treatment at a university hospital in southern Thailand …
(OSCC) patients attending for treatment at a university hospital in southern Thailand …