Loss of urate oxidase activity in hominoids and its evolutionary implications
M Oda, Y Satta, O Takenaka… - Molecular biology and …, 2002 - academic.oup.com
We have determined and compared the promoter, coding, and intronic sequences of the
urate oxidase (Uox) gene of various primate species. Although we confirm the previous …
urate oxidase (Uox) gene of various primate species. Although we confirm the previous …
A human XY homologous region encodes “amelogenin”
Y Nakahori, O Takenaka, Y Nakagome - Genomics, 1991 - Elsevier
Results of cloning and sequencing of genomic sequences from the X and Y chromosomes
that encode the tooth enamel gene amelogenin (both AMG and AMGL) are described. Three …
that encode the tooth enamel gene amelogenin (both AMG and AMGL) are described. Three …
Perampanel: a novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy
T Hanada, Y Hashizume, N Tokuhara, O Takenaka… - …, 2011 - Wiley Online Library
Purpose: To assess the pharmacology of perampanel and its antiseizure activity in
preclinical models. Perampanel [2‐(2‐oxo‐1‐phenyl‐5‐pyridin‐2‐yl‐1,2‐dihydropyridin‐3‐yl) …
preclinical models. Perampanel [2‐(2‐oxo‐1‐phenyl‐5‐pyridin‐2‐yl‐1,2‐dihydropyridin‐3‐yl) …
Conflict among individual mitochondrial proteins in resolving the phylogeny of eutherian orders
…, PJ Waddell, M Westerman, O Takenaka… - Journal of Molecular …, 1998 - Springer
The phylogenetic relationship among primates, ferungulates (artiodactyls + cetaceans +
perissodactyls + carnivores), and rodents was examined using proteins encoded by the H …
perissodactyls + carnivores), and rodents was examined using proteins encoded by the H …
Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates
Since the process of becoming dead genes or pseudogenes (pseudogenization) is
irreversible and can occur rather rapidly under certain environmental circumstances, it is one …
irreversible and can occur rather rapidly under certain environmental circumstances, it is one …
Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1, 2-dihydropyridin-3-yl) benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4 …
…, K Kawano, K Ito, Y Norimine, O Takenaka… - Journal of medicinal …, 2012 - ACS Publications
Dysfunction of glutamatergic neurotransmission has been implicated in the pathogenesis of
epilepsy and numerous other neurological diseases. Here we describe the discovery of a …
epilepsy and numerous other neurological diseases. Here we describe the discovery of a …
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions
The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-drug
interactions (DDIs) is an indispensable part of drug development. We previously …
interactions (DDIs) is an indispensable part of drug development. We previously …
Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide …
Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic
uptake of many drugs, and the evaluation of OATP1B1-mediated drug-drug interactions (DDIs) …
uptake of many drugs, and the evaluation of OATP1B1-mediated drug-drug interactions (DDIs) …
Infanticide by resident males and female counter-strategies in wild Japanese macaques (Macaca fuscata)
…, R Thomsen, K Matsubayashi, O Takenaka - Behavioral Ecology and …, 2000 - Springer
Infanticide was observed for the first time in a wild, non-provisioned troop of Japanese
macaques on Yakushima Island, Japan. Eight adult resident males attacked unweaned infants in …
macaques on Yakushima Island, Japan. Eight adult resident males attacked unweaned infants in …
L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein
M Hattori, S Kuhara, O Takenaka, Y Sakaki - Nature, 1986 - nature.com
Primate and rodent genomes contain a family of highly repetitive, long interspersed sequences,
designated the L1 family or LINE-1 (refs 1–4). Characteristic features of the L1 family …
designated the L1 family or LINE-1 (refs 1–4). Characteristic features of the L1 family …