Biotransformation enzymes in human intestine: critical low levels in the colon?

WH Peters, L Kock, FM Nagengast, PG Kremers - Gut, 1991 - gut.bmj.com
Biotransformation or drug-metabolising enzymes have an important function in the detoxication
of ingested toxic, carcinogenic, or tumour promoting compounds. Enzyme activity and …

Cytochromes P-450 in the intestinal mucosa of man

WHM Peters, PG Kremers - Biochemical pharmacology, 1989 - Elsevier
… Lanes 1 and 12 contain identical samples of hepatic microsomes (4 pg protein) and lanes
2-11 contain small intestinal microsomes from the same patient (20 pg protein each), orig…

Expression of drug-metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa

…, HMJ Roelofs, T Wobbes, FM Nagengast, PG Kremers - Gastroenterology, 1992 - Elsevier
… (20 pg protein) from normal mucosa and colorectal tumors were subjected to SDS f PAGE
(7% … Lane M contains 10 pg of a P-170 glycoprotein marker (P-glycocheck). The location of P-…

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

PH Beaune, PG Kremers, LS Kaminsky… - Drug metabolism and …, 1986 - ASPET
Concentrations of three human liver microsomal cytochrome P-450 isozymes and 20 different
monooxygenase activities were determined in human liver microsomal preparations. The …

Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015

EE Page, JA Kremer Hovinga, DR Terrell… - Blood …, 2017 - ashpublications.org
Our objective was to describe new observations from the Oklahoma Thrombotic Thrombocytopenic
Purpura (TTP) Registry experience (November 1995 through December 2015) on the …

[HTML][HTML] Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in …

…, MV Martin, PH Beaune, P Kremers… - Journal of Biological …, 1986 - Elsevier
… The costs of publication of this article were defrayed in part by the payment of page charges.
This article must therefore be hereby marked “advertisement†in accordance with 18 …

Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a …

…, R Capps, K Smith, J Caldwell, J Kremer - Annals of the …, 2005 - ard.bmj.com
… Red blood cell MTX PG concentrations (expressed as nmol/l … that MTX triglutamate (MTX
PG 3 ) is the predominant … PG concentrations expressed as the sum of MTX PG 3 + MTX …

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis

…, N Greenstein, J Kremer - Arthritis & Rheumatism …, 2006 - Wiley Online Library
Objective To evaluate the contribution of metabolites (methotrexate [MTX] and folate
polyglutamate [PG] levels) and pharmacogenetic biomarkers in the folate pathway to the effects of …

The cerebrospinal fluid amyloid β42/40 ratio in the differentiation of alzheimer's disease from non-alzheimer's dementia

…, D Slats, JMC Sjogren, BPH Kremer… - Current Alzheimer …, 2010 - ingentaconnect.com
… Results: Mean Aβ40 levels were 2850 pg/ml in VaD and 2830 pg/ml in DLB patients, both …
2875 pg/ml; n=32). The lower limit of detection was for Aβ42 50 pg/ml and for Aβ40 22 pg/ml. …

[HTML][HTML] Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients

…, PG Dean, FG Cosio, MJ Gandhi, W Kremers… - American journal of …, 2011 - Elsevier
Sensitized renal transplant recipients with high levels of donor-specific alloantibody (DSA)
commonly develop antibody-mediated rejection (AMR), which may cause acute graft loss or …