Scientists studying mammals have developed a stepwise approach to predict in vivo hepatic
clearance from measurements of in vitro hepatic biotransformation. The resulting clearance …

The branchial elimination of pentachloroethane and four congeneric polychlorinated biphenyls
by rainbow trout was measured using a fish respirometer-metabolism chamber and an …

… Based on this analysis, we recommend use of the binding algorithm given by Fitzsimmons
… fractions in blood (ie, the equation given by Fitzsimmons et al. 27) and a revised estimate of …

The occurrence of pharmaceuticals in the environment presents a challenge of growing
concern. In contrast to many industrial compounds, pharmaceuticals undergo extensive testing …

Hypothetical in vitro biotransformation rate and affinity values for fish were extrapolated to a
set of in vivo whole‐body metabolism rate constants. A one‐compartment model was then …

Scientific literature from the past 25 years was searched to obtain in vitro biotransformation
rate and affinity data for fish. To maximize the environmental relevance of this dataset, we …

Isolated perfused trout livers were used to evaluate in vitro-in vivo metabolism extrapolation
procedures for fish. In vitro depletion rates for 6 polycyclic aromatic hydrocarbons (PAHs) …

A physiologically based toxicokinetic (PBTK) model was developed to describe dietary uptake
of hydrophobic organic compounds by fish. The gastrointestinal (GI) tract was modeled …

Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were
dosed with perfluorooctanoate (PFOA) by intra-arterial (ia) injection and sampled to obtain …

Rainbow trout (Oncorhynchus mykiss) confined to respirometer‐metabolism chambers were
dosed with perfluorooctane sulfonate (PFOS) by intra‐arterial injection and sampled to …