[HTML][HTML] Use of reporter genes for optical measurements of neoplastic disease in vivo

CH Contag, D Jenkins, PR Contag, RS Negrin - Neoplasia, 2000 - Elsevier
Revealing the cellular and molecular changes associated with cancer, as they occur in
intact living animal models of human neoplastic disease, holds tremendous potential for …

Photonic detection of bacterial pathogens in living hosts

CH Contag, PR Contag, JI Mullins… - Molecular …, 1995 - Wiley Online Library
The study of pathogenic is often limited to ex vivo assays and cell‐culture correlates. A greater
understanding of infectious diseases would be facilitated by in vivo analyses. Therefore, …

Visualizing gene expression in living mammals using a bioluminescent reporter

CH Contag, SD Spilman, PR Contag… - Photochemistry and …, 1997 - Wiley Online Library
… in all tissues over the first few weeks of life (Contag et aZ., unpublished results). The reliance
Contag, CH and PR Contag (1996) Viewing disease progression through a bioluminescent …

Monitoring Bioluminescent Staphylococcus aureusInfections in Living Mice Using a Novel luxABCDEConstruct

…, MJ Hawkinson, TF Purchio, PR Contag - Infection and …, 2000 - Am Soc Microbiol
Strains of Staphylococcus aureus were transformed with plasmid DNA containing a Photorhabdus
luminescens luxoperon (luxABCDE) that was genetically modified to be functional in …

Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis

…, SF Yu, J Dusich, T Purchio, PR Contag - Clinical & experimental …, 2003 - Springer
Contag PR. Whole-animal cellular and molecular imaging to accelerate drug development.
… Zhang W, Contag PR, Hardy J et al. Selection of potential therapeutics based on in vivo …

Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent Streptococcus pneumoniaeTransformed with a Novel Gram-Positive lux …

…, MG Caparon, M Lipsitch, PR Contag - Infection and …, 2001 - Am Soc Microbiol
Animal studies with Streptococcus pneumoniae have provided valuable models for drug
development. In order to monitor long-term pneumococcal infections noninvasively in living mice…

Direct continuous method for monitoring biofilm infection in a mouse model

…, TR Parr Jr, PR Contag - Infection and …, 2003 - Am Soc Microbiol
We have developed a rapid, continuous method for real-time monitoring of biofilms, both in
vitro and in a mouse infection model, through noninvasive imaging of bioluminescent …

Whole-animal cellular and molecular imaging to accelerate drug development

PR Contag - Drug discovery today, 2002 - Elsevier
… I would like to thank John Thomas for research, editing and manuscript preparation,
Robin Kurka for manuscript preparation and Christopher Contag for comments and editing …

Validation of a Noninvasive, Real-Time Imaging Technology Using Bioluminescent Escherichia coli in the Neutropenic Mouse Thigh Model of Infection

…, CL McMillian, PR Contag… - Antimicrobial agents …, 2001 - Am Soc Microbiol
A noninvasive, real-time detection technology was validated for qualitative and quantitative
antimicrobial treatment applications. Thelux gene cluster of Photorhabdus luminescenswas …

Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse

N Zhang, Z Fang, PR Contag, AF Purchio, DB West - Blood, 2004 - ashpublications.org
The vascular endothelial growth factor-2 (VEGFR2) gene is transcriptionally regulated during
angiogenesis. The ability to monitor and quantify VEGFR2 expression in vivo may facilitate …