Endothelial nitric oxide synthase (eNOS) is an important modulator of angiogenesis and
vascular tone [1]. It is stimulated by treatment of endothelial cells in a phosphatidylinositol 3-…

A rat heme oxygenase (HO-1) gene without the sequence coding for the last 23 amino acids
has been constructed and expressed behind the pho A promoter in Escherichia coli. The …

Destruction of hepatic cytochrome P-450 during catalytic processing of 1-amino-benzotriazole
is accompanied by an equal loss of microsomal haem but not by loss of cytochrome b5, or …

Hemoglobin-catalyzed phenylhydrazine oxidation, a model for Heinz-body hemolytic anemias,
is known to result in hemoglobin degradation and erythrocyte lysis. The catalytic reaction …

Incubation of horseradish peroxidase with phenylhydrazine and H2O2 markedly depresses
the catalytic activity and the intensity, but not position, of the Soret band. Approximately 11-…

… Jack Peisach, has been shown by SDS-PAGE not to give dimeric species when incubated
under the conditions described in this study (PR Ortiz de Montellano and CE Catalano, …

Cytochrome P-450 is destroyed during catalytic oxidation of several 4-substituted 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine
substrates. A qualitative correlation has been …

Reaction of horse myoglobin with H 2 O 2 oxidizes the iron to the ferryl (Fe(IV)=O) state and
produces a protein radical that is rapidly dissipated by poorly understood mechanisms. As …

This study evaluated the ability of 17-octadecynoic acid (17-ODYA) to inhibit the metabolism
of arachidonic acid by cytochrome P450 in renal cortical microsomes of rats, and …

It is a singular honor to have been selected as the recipient of the 1994 Bernard B. Brodie
Award and thereby to be associated with the distinguished list of previous awardees(1-8). I …