User profiles for P. Artursson
Per ArturssonUppsala university Verified email at farmaci.uu.se Cited by 39065 |
Caco-2 monolayers in experimental and theoretical predictions of drug transport
P Artursson, K Palm, K Luthman - Advanced drug delivery reviews, 2001 - Elsevier
This review examines the use of Caco-2 monolayers in the prediction of intestinal drug
absorption. First, the different routes of drug transport in Caco-2 monolayers are compared with …
absorption. First, the different routes of drug transport in Caco-2 monolayers are compared with …
Coexistence of passive and carrier-mediated processes in drug transport
K Sugano, M Kansy, P Artursson, A Avdeef… - Nature reviews Drug …, 2010 - nature.com
… Other specific models of membrane transport such as genetically transfected MDCK cells
that express P-gp (MDCK-MDR1 cells) can also be used to determine how a compound may …
that express P-gp (MDCK-MDR1 cells) can also be used to determine how a compound may …
[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
P Artursson, J Karlsson - Biochemical and biophysical research …, 1991 - Elsevier
Monolayers of a well differentiated human intestinal epithelial cell line, Caco-2, were used
as a model to study passive drug absorption across the intestinal epithelium. Absorption rate …
as a model to study passive drug absorption across the intestinal epithelium. Absorption rate …
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
I Hubatsch, EGE Ragnarsson, P Artursson - Nature protocols, 2007 - nature.com
… of the P app value. A lower mass balance will result in underestimation of the P app values
… permeability (P app,ba /P app,ab ). The uptake ratio is the inverse of the efflux ratio, that is, …
… permeability (P app,ba /P app,ab ). The uptake ratio is the inverse of the efflux ratio, that is, …
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco‐2) cells
PER Artursson - Journal of pharmaceutical sciences, 1990 - Wiley Online Library
… of the distribution coefficients for six p-blockers. The insert … model and those obtained with
the same p-blockers in a rat in … the hydrophilic but not the hydrophobic p-blockers.30 Moreover…
the same p-blockers in a rat in … the hydrophilic but not the hydrophobic p-blockers.30 Moreover…
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production,
damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to …
damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to …
Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement
…, AG deBoer, KM Vårum, P Artursson - Pharmaceutical …, 1997 - Springer
Purpose. It has recently been shown that the absorption enhancing and toxic effects of chitosans
are dependent on their chemical composition. In this study, the mechanisms underlying …
are dependent on their chemical composition. In this study, the mechanisms underlying …
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial …
…, P Garberg, B Sjöström, B Lundgren, P Artursson - … of Pharmacology and …, 2001 - ASPET
This investigation describes the expression and interindividual variability in transcript levels
of multiple drug efflux systems in the human jejunum and compares the expression profiles …
of multiple drug efflux systems in the human jejunum and compares the expression profiles …
Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers
Nonviral gene delivery systems based on conventional high-molecular-weight chitosans
are efficient after lung administration in vivo, but have poor physical properties such as …
are efficient after lung administration in vivo, but have poor physical properties such as …