Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising
globally, the reasons for which are unclear. It appears to represent a unique disease process …

… half-life, it has been recently shown that coadministration of esmolol had no significant (p …
Bodor N, Buchwald P. Molecular size based approach to estimate partition properties for …

… For a more accurate interpretation, we present here a comprehensive and reevaluated
correlation between log P o/w and in vivo permeability data of rat brain capillaries estimated from …

… , 14.6% [95% CI, 3.5% to 25.6%]; P = .01) for patients who did not have fecal peritonitis. The
length … difference in primary outcome between the study groups with a P value less than .01. …

Currently available human tumour cell line panels consist of a small number of lines in each
lineage that generally fail to retain the phenotype of the original patient tumour. Here we …

Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …

… account for the different solubilities of oxygen in the membrane and in the media; results are
presented after recalibrating concentration in the membrane with the partition coefficient K p …

Cells promote polarized growth by activation of Rho-family protein Cdc42 at the cell membrane.
We combined experiments and modeling to study bipolar growth initiation in fission yeast…

As the ultimate function of proteins depends to a great extent on their binding partners,
protein–protein interactions (PPIs) represent a treasure trove of possible new therapeutic targets. …

Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth
but is elevated in colorectal cancer. The aim of this review was to define the current role of …