Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

… To whom correspondence should be addressed (e-mail paavo.honkakoski!uku.fi). …
Polyaromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induce CYP1A and …

… Negishi M, Honkakoski P. Induction of drug metabolism by nuclear receptor CAR:
molecular mechanisms and implications for drug research. Eur J Pharm Sci 2000; 11: 259ą64. …

The endogenous CYP2B6 gene becomes phenobarbital (PB) inducible in androstenol-treated
HepG2 cells either transiently or stably transfected with a nuclear receptor CAR …

PBREM, the phenobarbital-responsive enhancer module of the cytochrome P-450 Cyp2b10
gene, contains two potential nuclear receptor binding sites, NR1 and NR2. Consistent with …

It has been shown that extracellular glycosaminoglycans (GAGs) limit the gene transfer by
cationic lipids and polymers. The purpose of this study was to clarify how interactions with …

Complexes of DNA with cationic lipids and cationic polymers are frequently used for gene
transfer. Extracellular interactions of the complexes with anionic glycosaminoglycans (GAGs) …

… P-glycoprotein is an efflux transporter encoded by the multidrug resistance gene (MDR1).
It was first found in tumour cells (Tanigawara, 2000) but is expressed at significant levels also …

… We found that NFI and C/EBPα could bind to 32 P-labeled pC element in gel shift assays
since antibodies raised against these transcription factors were able to supershift some of the …

… The significance was considered when p < 0.05. A p-value larger than 0.05 (p > 0.05) was
taken … Without metabolism, the toxicity of IFO to GBM cells was considerably weaker (p < 0.01). …