This review represents an update of the nomenclature system for the UDP glucuronosyltransferase
gene superfamily, which is based on divergent evolution. Since the previous review …

Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases,
have been identified in the human, mouse and rat genomes and in other mammalian …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which are
divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of the …

UDP–Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic
reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates …

Glucuronidation is a major metabolic pathway for a large number of drugs in humans.
Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-…

The glucuronidation kinetics of the prototypic substrates 4-methylumbelliferone (4MU) and 1-naphthol
(1NP) by human UDP-glucuronosyltransferases (UGT) 1A1, 1A3, 1A4, 1A6, 1A7, …

… after removal of the transmembrane domain (R Meech and PI Mackenzie, unpubl. obs.,
1997). The amino-terminal half of UGT seems to contain this region of membrane interaction. …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

UDP-Glucuronosyltransferase (UGT), the microsomal enzyme responsible for glucuronidation
reactions, exists as a superfamily of enzymes. Genetic polymorphism has been described …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …